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Abstract

In 358 participants of the Tasmanian Healthy Brain Project, we quantified the cognitive consequences of engaging in varying loads of university-level education in later life, and investigated whether or not BDNF Val66Met affected outcomes. Assessment of neuropsychological, health, and psychosocial function was undertaken at baseline, 12-month, and 24-month follow-up. Education load was positively associated with change in language processing performance, but this effect did not reach statistical significance (P = 0.064). The BDNF Val66Met polymorphism significantly moderated the extent to which education load was associated with improved language processing (P = 0.026), with education load having a significant positive relationship with cognitive change in BDNF Met carriers but not in BDNF Val homozygotes. In older adults who carry BDNF Met, engaging in university-level education improves language processing performance in a load-dependent manner.

Item Type:	Article
Authors/Creators:	Ward, DD and Summers, MJ and Valenzuela, MJ and Srikanth, VK and Summers, JJ and King, AE and Ritchie, K and Robinson, AL and Vickers, JC
Keywords:	education, BDNF, cognitive, university, intervention
Journal or Publication Title:	The Journal of Prevention of Alzheimer's Disease
Publisher:	Editions S E R D I
ISSN:	2274-5807
DOI / ID Number:	https://doi.org/10.14283/jpad.2019.40
Copyright Information:	Copyright 2020 Serdi and Springer Nature Switzerland AG
Related URLs:	Google Scholar: Ward, DD UTAS Profile: Ward, DD UTAS Profile: Summers, JJ UTAS Profile: King, AE UTAS Profile: Robinson, AL UTAS Profile: Vickers, JC
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