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Abstract

Importance: Atropine eyedrops are a promising treatment for slowing myopia progression in East Asian children. However, its effects on children in Australia, including those of non-Asian background, have not been well-studied.Background: The Western Australia Atropine for the Treatment of Myopia (WA-ATOM) study aims to determine the efficacy and long-term effects of low-dose atropine eyedrops in myopia control. This paper describes the study rationale, methodology and participant baseline characteristics.Design: Single-centre, double-masked, randomized controlled trial.Participants: Children (6-16 years) with spherical equivalent ≤-1.50 D in each eye, astigmatism ≤1.50 D and myopia progression by ≥0.50 D/year.Methods: Enrolled children were randomly assigned 2:1 to receive 0.01% atropine or placebo eyedrops. Participants are examined every 6 months during first 3 years of the study (2-year treatment phase followed by a 1-year washout phase), and then at a 5-year follow-up (2 years after the end of the washout phase).Main outcome measures: Annual progression rate of myopia and axial length, tolerability to eyedrops and incidence and severity of unwanted effects.Results: Out of 311 children who were referred, 242 were suitable for study participation, and 153 were subsequently enrolled. The baseline characteristics of enrolled participants are presented.Conclusions and relevance: Outcomes of the WA-ATOM study will inform on the efficacy, tolerability, safety and long-term effects of low-dose atropine eyedrops in myopia control in Australian children. The impact of ocular sun exposure, iris colour and parental myopia on the efficacy of low-dose atropine will also be assessed.

Item Type:	Article
Authors/Creators:	Lee, SSY and Mackey, DA and Lingham, G and Crewe, JM and Richards, MD and Chen, FK and Charng, J and Ng, F and Flitcroft, I and Loughman, JJ and Azuara-Blanco, A and Logan, NS and Hammond, CJ and Chia, A and Truong, TT and Clark, A
Keywords:	atropine eyedrop, myopia, myopia control, myopia treatment
Journal or Publication Title:	Clinical and Experimental Ophthalmology
Publisher:	Wiley-Blackwell Publishing Asia
ISSN:	1442-6404
DOI / ID Number:	10.1111/ceo.13736
Copyright Information:	© 2020 Royal Australian and New Zealand College of Ophthalmologists
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