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Mixed alkoxy/hydroxy 1,8-naphthalimides: expanded fluorescence colour palette and in vitro bioactivity
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Rudebeck, EE, Cox, RP, Bell, TDM, Acharya, R, Feng, Z, Gueven, N 
ORCID: 0000-0003-3782-767X, Ashton, TD and Pfeffer, FM 2020
, 'Mixed alkoxy/hydroxy 1,8-naphthalimides: expanded fluorescence colour palette and in vitro bioactivity'
, Chemical Communications
, doi: 10.1039/d0cc01251c.
ORCID: 0000-0003-3782-767X, Ashton, TD and Pfeffer, FM 2020
, 'Mixed alkoxy/hydroxy 1,8-naphthalimides: expanded fluorescence colour palette and in vitro bioactivity'
, Chemical Communications
, doi: 10.1039/d0cc01251c.
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Abstract
An efficient and functional group tolerant route to access hydroxy1,8-naphthalimides has been used to synthesise a range of monoand disubstituted hydroxy-1,8-naphthalimides with fluorescenceemissions covering the visible spectrum. The dialkoxy substitutedcompounds prepared possess high quantum yields (up to 0.95) andlong fluorescent lifetimes (up to 14 ns). The method has been usedto generate scriptaid analogues that successfully inhibit HDAC6in vitro with tubulin acetylation assays confirming that thesecompounds are more effective than tubastatin.
| Item Type: | Article |
|---|---|
| Authors/Creators: | Rudebeck, EE and Cox, RP and Bell, TDM and Acharya, R and Feng, Z and Gueven, N and Ashton, TD and Pfeffer, FM |
| Keywords: | HDAC6 inhibitors |
| Journal or Publication Title: | Chemical Communications |
| Publisher: | Royal Soc Chemistry |
| ISSN: | 1359-7345 |
| DOI / ID Number: | 10.1039/d0cc01251c |
| Copyright Information: | © The Royal Society of Chemistry 2020 |
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| Item Statistics: | View statistics for this item |
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