Open Access Repository

Mixed alkoxy/hydroxy 1,8-naphthalimides: expanded fluorescence colour palette and in vitro bioactivity

Rudebeck, EE, Cox, RP, Bell, TDM, Acharya, R, Feng, Z, Gueven, N ORCID: 0000-0003-3782-767X, Ashton, TD and Pfeffer, FM 2020 , 'Mixed alkoxy/hydroxy 1,8-naphthalimides: expanded fluorescence colour palette and in vitro bioactivity' , Chemical Communications , doi: 10.1039/d0cc01251c.

Full text not available from this repository.

Abstract

An efficient and functional group tolerant route to access hydroxy1,8-naphthalimides has been used to synthesise a range of monoand disubstituted hydroxy-1,8-naphthalimides with fluorescenceemissions covering the visible spectrum. The dialkoxy substitutedcompounds prepared possess high quantum yields (up to 0.95) andlong fluorescent lifetimes (up to 14 ns). The method has been usedto generate scriptaid analogues that successfully inhibit HDAC6in vitro with tubulin acetylation assays confirming that thesecompounds are more effective than tubastatin.

Item Type: Article
Authors/Creators:Rudebeck, EE and Cox, RP and Bell, TDM and Acharya, R and Feng, Z and Gueven, N and Ashton, TD and Pfeffer, FM
Keywords: HDAC6 inhibitors
Journal or Publication Title: Chemical Communications
Publisher: Royal Soc Chemistry
ISSN: 1359-7345
DOI / ID Number: 10.1039/d0cc01251c
Copyright Information:

© The Royal Society of Chemistry 2020

Related URLs:
Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page
TOP