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Synbiotic supplementation with prebiotic green banana resistant starch and probiotic Bacillus coagulans spores ameliorates gut inflammation in mouse model of inflammatory bowel diseases

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Shinde, TS ORCID: 0000-0002-8551-5841, Perera, APP ORCID: 0000-0002-3674-9940, Vemuri, R ORCID: 0000-0002-3238-426X, Gondalia, SV, Beale, DJ, Karpe, AV, Shastri, S, Basheer, W, Southam, B, Eri, R ORCID: 0000-0003-1688-8043 and Stanley, R ORCID: 0000-0002-2279-5022 2020 , 'Synbiotic supplementation with prebiotic green banana resistant starch and probiotic Bacillus coagulans spores ameliorates gut inflammation in mouse model of inflammatory bowel diseases' , European Journal of Nutrition , doi: 10.1007/s00394-020-02200-9.

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Abstract

Purpose:The research goal is to develop dietary strategies to help address the growing incidence of inflammatory bowel diseases (IBD). This study has investigated the effectiveness of green banana resistant starch (GBRS) and probiotic Bacillus coagulans MTCC5856 spores for the amelioration of dextran-sulfate sodium (DSS)-induced colitis in mice.Methods: Eight-week-old C57BL/6 mice were fed standard rodent chow diet supplemented with either B. coagulans, GBRS or its synbiotic combination. After 7 days supplementation, colitis was induced by adding 2% DSS in drinking water for 7 days while continuing the supplemented diets. Animal health was monitored and after 14 days all animals were sacrifced to measure the biochemical and histochemical changes associated with each supplement type.Results:The disease activity index and histological damage score for DSS-control mice (6.1, 17.1, respectively) were significantly higher (p B. coagulans (-52%, -58% respectively) or GBRS (-57%, -26%, respectively) alone. Compared to DSS-control synbiotic supplementation significantly (pB. coagulans alone could not induce additional levels of short-chain fatty acid (SCFA) production beyond the caecum, the synbiotic combination with GBRS resulted in substantial increased SCFA levels across the whole length of the colon.Conclusion:The synbiotic supplementation with B. coagulans and GBRS ameliorated the overall inflammatory status of the experimental IBD model via synergistic functioning. This supports researching its application in mitigating inflammation in human IBD.

Item Type: Article
Authors/Creators:Shinde, TS and Perera, APP and Vemuri, R and Gondalia, SV and Beale, DJ and Karpe, AV and Shastri, S and Basheer, W and Southam, B and Eri, R and Stanley, R
Keywords: synbiotic, prebiotic, probiotic, infammatory bowel diseases, bacillus spores, green banana, resistant starch, mucosal barrier, short-chain fatty acids
Journal or Publication Title: European Journal of Nutrition
Publisher: Dr Dietrich Steinkopff Verlag
ISSN: 1436-6207
DOI / ID Number: 10.1007/s00394-020-02200-9
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Copyright 2020 The Author(s)

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