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If human brain organoids are the answer to understanding dementia, what are the questions?

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Ooi, L, Dottori, M, Cook, AL ORCID: 0000-0003-1770-7910, Engel, M, Gautam, V, Grubman, A, Hernandez, D, King, AE ORCID: 0000-0003-1792-0965, Maksour, S, Targa Dias Anastacio, H, Balez, R, Pebay, A, Pouton, C, Valenzuela, M, White, A and Williamson, R 2020 , 'If human brain organoids are the answer to understanding dementia, what are the questions?' , The Neuroscientist , pp. 1-17 , doi: 10.1177/1073858420912404.

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Abstract

Because our beliefs regarding our individuality, autonomy, and personhood are intimately bound up with our brains, there is a public fascination with cerebral organoids, the "mini-brain," the "brain in a dish". At the same time, the ethical issues around organoids are only now being explored. What are the prospects of using human cerebral organoids to better understand, treat, or prevent dementia? Will human organoids represent an improvement on the current, less-than-satisfactory, animal models? When considering these questions, two major issues arise. One is the general challenge associated with using any stem cell-generated preparation for in vitro modelling (challenges amplified when using organoids compared with simpler cell culture systems). The other relates to complexities associated with defining and understanding what we mean by the term "dementia." We discuss 10 puzzles, issues, and stumbling blocks to watch for in the quest to model "dementia in a dish."

Item Type: Article
Authors/Creators:Ooi, L and Dottori, M and Cook, AL and Engel, M and Gautam, V and Grubman, A and Hernandez, D and King, AE and Maksour, S and Targa Dias Anastacio, H and Balez, R and Pebay, A and Pouton, C and Valenzuela, M and White, A and Williamson, R
Keywords: stem cells, organoidu, dementia, organoids, induced pluripotent stem cells, Alzheimer’s disease, neurodegeneration, cerebral, cortical, disease model
Journal or Publication Title: The Neuroscientist
Publisher: Sage Publications Inc
ISSN: 1073-8584
DOI / ID Number: 10.1177/1073858420912404
Copyright Information:

© The Author(s) 2020. This is an open access article published under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license (https://creativecommons.org/licenses/by-nc/4.0/)

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