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Application of a tubular copper electrode as a potentiometric detector in the determination of amino acids by high performance liquid chromatography.

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Alexander, PW, Haddad, PR, Low, GKC and Maitra, C 1981 , 'Application of a tubular copper electrode as a potentiometric detector in the determination of amino acids by high performance liquid chromatography.' , Journal of Chromatography A, vol. 209, no. 1 , pp. 29-39 , doi: 10.1016/S0021-9673(00)80420-3.

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Abstract

A copper tubular electrode (CTE) has been used as a potentiometric detector in the determination of amino acids by reversed-phase high-performance liquid chromatography. The reference electrode was an electrically grounded tubular platinum electrode inserted in the flow stream. Comparison with a variable-wavelength UV absorbance detector showed that the CTE gave comparable response time and sensitivity, but was much more selective, showing response only to copper-binding molecules. The CTE has been applied to the analysis of urine and an intravenous amino acid preparation; no sample pre-treatment was required, other than filtration. Microgram quantities of amino acids were readily detected by using the CTE.

Item Type: Article
Authors/Creators:Alexander, PW and Haddad, PR and Low, GKC and Maitra, C
Journal or Publication Title: Journal of Chromatography A
ISSN: 0021-9673
DOI / ID Number: 10.1016/S0021-9673(00)80420-3
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