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Abstract

The association of different antihypertensive regimens with blood pressure (BP) control is not well-described among community-dwelling older adults with low comorbidity. We examined antihypertensive use and BP control in 10 062 treated hypertensives from Australia and the United States (US) using baseline data from the ASPirin in Reducing Events in the Elderly (ASPREE) trial. Renin-angiotensin system (RAS) drugs were the most prevalently used antihypertensive in both countries (Australia: 81.7% of all regimens; US: 62.9% of all regimens; P P P P = .002; diuretic monotherapy: BP control = 45.2% vs 64.5%; P = .001; and RAS blocker/diuretic combo: BP control = 50.2% vs 65.6%; P = .001). Our findings highlight variation in antihypertensive use in older adults treated for hypertension, with implications for BP control. Differences in BP control that were observed may be influenced, in part, by reasons other than choice of specific regimens.

Item Type:	Article
Authors/Creators:	Ernst, ME and Chowdhury, EK and Nelson, MR and Reid, CM and Margolis, KL and Beilin, L and Stocks, NP and Murray, AM and Wolfe, R and Lockery, JE and Orchard, SG and Woods, RL and McNeil, JJ
Keywords:	antihypertensive therapy, blood pressure control, hypertension in older adults
Journal or Publication Title:	Journal of Clinical Hypertension
Publisher:	Le Jacq Communications, Inc.
ISSN:	1524-6175
DOI / ID Number:	10.1111/jch.13934
Copyright Information:	© 2020 Wiley Periodicals LLC
Related URLs:	Google Scholar: Nelson, MR UTAS Profile: Nelson, MR
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