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Cancer history and risk factors in healthy older people enrolling in the ASPREE clinical trial

Orchard, SG, Lockery, JE, Gibbs, P, Polekhina, G, Wolfe, R, Zalcberg, J, Haydon, A, McNeil, JJ, Nelson, MR ORCID: 0000-0001-9941-7161, Reid, CM, Kirpach, B, Murray, AM and Woods, RL 2020 , 'Cancer history and risk factors in healthy older people enrolling in the ASPREE clinical trial' , Contemporary Clinical Trials, vol. 96 , pp. 1-7 , doi: 10.1016/j.cct.2020.106095.

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Background: Cancer is a leading cause of death globally. Given the elevated risk of cancer with age and an ageing population, it is important to understand the changing burden of cancer in older populations. The ASPirin in Reducing Events in the Elderly (ASPREE) study randomised healthy older individuals to 100 mg aspirin or placebo, with clinical outcomes and disability-free survival endpoints. Detailed baseline data provides a rare opportunity to explore cancer burden in a uniquely healthy older population. Methods: At study enrolment (2010-2014), self-reported personal cancer history, cancer type and cancer risk factor data were sought from 19,114 participants (Australia, n = 16,703; U.S., n = 2411). Eligible participants were healthy, free of major diseases and expected to survive 5 years. Results: Nearly 20% of enrolling ASPREE participants reported a prior cancer diagnosis; 18% of women and 22% of men, with women diagnosed younger (16% vs 6% of diagnoses Conclusions: Personal cancer history in healthy older ASPREE participants was as expected for the most common cancer types in the respective populations, but was not necessarily aligned with known risk factors. We attribute this to survivor bias, likely driven by entry criteria.

Item Type: Article
Authors/Creators:Orchard, SG and Lockery, JE and Gibbs, P and Polekhina, G and Wolfe, R and Zalcberg, J and Haydon, A and McNeil, JJ and Nelson, MR and Reid, CM and Kirpach, B and Murray, AM and Woods, RL
Keywords: aspirin, cancer epidemiology, cancer prevalence, cancer risk factors, selection criteria, survivor bias
Journal or Publication Title: Contemporary Clinical Trials
Publisher: Elsevier Inc.
ISSN: 1551-7144
DOI / ID Number: 10.1016/j.cct.2020.106095
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© 2020 Elsevier Inc. All rights reserved.

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