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Skin photosensitivity is associated with 25-Hydroxyvitamin D and BMD but not fractures independent of melanin density in older caucasian adults

Thompson, MJW, Jones, G ORCID: 0000-0002-9814-0006, Balogun, SA ORCID: 0000-0001-6415-5536 and Aitken, DA ORCID: 0000-0001-5685-7634 2020 , 'Skin photosensitivity is associated with 25-Hydroxyvitamin D and BMD but not fractures independent of melanin density in older caucasian adults' , Calcified Tissue International , pp. 1-10 , doi: 10.1007/s00223-020-00728-w.

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Abstract

Whether skin photosensitivity modulates sun exposure behaviours, consequent vitamin D status and skeletal health outcomes independently of constitutive pigmentation have not been systematically investigated. 1072 community-dwelling adults aged 50-80 years had skin photosensitivity quantified by questionnaire and melanin density by spectrophotometry. Bone mineral density (BMD), falls risk and 25-hydroxyvitamin D (25OHD) were measured using DXA, short form physiological profile assessment and radioimmunoassay, respectively. Sun exposure and symptomatic fractures were assessed by questionnaire. Participants were followed up at 2.5 (n = 879), 5 (n = 767) and 10 (n = 571) years. Higher resistance to sunburn and greater ability to tan were associated with reduced sun protection behaviours (RR 0.87, p p p = 0.001 & RR 1.07, p = 0.001) and winter (RR 1.07, p = 0.001 & RR 1.08, p = 0.02) and fewer lifetime sunburns (RR 0.86, p p = 0.001). Higher resistance to sunburn was associated with lower total body (β = - 0.006, p = 0.047) and femoral neck (β = - 0.006, p = 0.038) BMD, but paradoxically, fewer prevalent fractures (RR 0.94, p = 0.042). Greater ability to tan was associated with higher 25OHD (β = 1.43, p = 0.04), lumbar spine (β = 0.014, p = 0.046) and total body (β = 0.013, p = 0.006) BMD, but not fracture or falls risk. These associations were independent of constitutive melanin density. Cutaneous photosensitivity was associated with sun exposure behaviours, cutaneous sequelae and, consequently, 25OHD and BMD in older Caucasian adults independent of constitutive melanin density. There was no consistent association with fracture outcomes, suggesting environmental factors are at least as important.

Item Type: Article
Authors/Creators:Thompson, MJW and Jones, G and Balogun, SA and Aitken, DA
Keywords: skin photosensitivity, phototype, melanin density, BMD, vitamin D, fractures
Journal or Publication Title: Calcified Tissue International
Publisher: Springer-Verlag
ISSN: 0171-967X
DOI / ID Number: 10.1007/s00223-020-00728-w
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© Springer Science+Business Media, LLC, part of Springer Nature 2020

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