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The impact of transcranial magnetic stimulation (TMS) on irritability occurring with acute major depressive disorder (MDD)

Pridmore, S ORCID: 0000-0002-9170-1798, Rybak, M, Morey, R and May, T 2020 , 'The impact of transcranial magnetic stimulation (TMS) on irritability occurring with acute major depressive disorder (MDD)' , Australasian Psychiatry , pp. 1-4 , doi: 10.1177/1039856220946606.

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Abstract

Objective:To examine the impact (if any) of a course of transcranial magnetic stimulation (TMS) on irritability occurring in association with acute major depressive disorder (MDD).Method:In a naturalistic study, patients with MDD according to DSM-5 criteria were given 20 daily TMS treatments. A visual analogue scale for irritability (VAS-I) was developed. Objective tools included the six-item Hamilton Depression Rating Scale (HAMDS6) and the Clinical Global Impression - Severity (CGI-S).Results:Fifty patients received 53 courses. Forty-seven courses achieved remission on both HAMD6 and CGI-S and six courses did not achieve remission with either. Irritability significantly reduced when MDD remission was achieved but was unchanged when remission was not achieved.Conclusion:TMS reduces irritability occurring in association with MDD when this treatment affects MDD remission, but not when remission is not affected.

Item Type: Article
Authors/Creators:Pridmore, S and Rybak, M and Morey, R and May, T
Keywords: transcranial magnetic stimulation, major depressive disorder, irritability
Journal or Publication Title: Australasian Psychiatry
Publisher: Sage Publications Ltd.
ISSN: 1039-8562
DOI / ID Number: 10.1177/1039856220946606
Copyright Information:

Copyright 2020 The Royal Australian and New Zealand College of Psychiatrists

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