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3-Year effect of weight loss via severe versus moderate energy restriction on body composition among postmenopausal women with obesity - the TEMPO Diet Trial

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Seimon, RV, Wild-Taylor, AL, McClintock, S, Harper, C, Gibson, AA, Johnson, NA, Fernando, HA, Markovic, TP, Center, JR, Franklin, J, Liu, PY, Grieve, SM, Lagopoulos, J, Caterson, ID, Byrne, NM ORCID: 0000-0001-5310-6640 and Sainsbury, A 2020 , '3-Year effect of weight loss via severe versus moderate energy restriction on body composition among postmenopausal women with obesity - the TEMPO Diet Trial' , Heliyon, vol. 6, no. 6 , pp. 1-11 , doi: 10.1016/j.heliyon.2020.e04007.

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Abstract

We have previously shown that a severely energy-restricted diet leads to greater loss of weight, fat, lean mass andbone mineral density (BMD) at 12 months in postmenopausal women with obesity than a moderately energyrestricted diet. We now aim to evaluate whether these effects are sustained longer term (ie, at 36 months).101 postmenopausal women were randomized to either 12 months of moderate (25 to 35%) energy restrictionwith a food-based diet (moderate intervention), or 4 months of severe (65 to 75%) energy restriction with a totalmeal replacement diet followed by moderate energy restriction for 8 months (severe intervention). Body weightand composition were measured at 0, 24 and 36 months. Participants in the severe intervention lost ~1.5 to 1.7times as much weight, waist circumference, whole-body fat mass and visceral adipose tissue compared to those inthe moderate intervention, and were 2.6 times more likely (42% versus 16%) to have lost 10% or more of theirinitial body weight at 36 months (P P P < 0.05), with this bone loss occurring in the first 12 months. Thus, severe energy restriction is moreeffective than moderate energy restriction for reducing weight and adiposity in postmenopausal women in thelong term (3 years), but attention to BMD loss in the first year is required.

Item Type: Article
Authors/Creators:Seimon, RV and Wild-Taylor, AL and McClintock, S and Harper, C and Gibson, AA and Johnson, NA and Fernando, HA and Markovic, TP and Center, JR and Franklin, J and Liu, PY and Grieve, SM and Lagopoulos, J and Caterson, ID and Byrne, NM and Sainsbury, A
Keywords: nutrition, diet, musculoskeletal system, endocrinology, clinical research, weight loss, body composition, diet-reducing, obesity, magnetic resonance imaging
Journal or Publication Title: Heliyon
Publisher: Elsevier Ltd
ISSN: 2405-8440
DOI / ID Number: 10.1016/j.heliyon.2020.e04007
Copyright Information:

Copyright 2020 Published by Elsevier Ltd. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/

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