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Perceived cognitive impairment is associated with sexual dysfunction in people with multiple sclerosis: a 2.5-year follow-up study of a large international cohort

Wu, J, Jelinek, GA, Weiland, T, Hedstrom, AK, Alfredsson, L, Neate, S, De Livera, A, Nag, N and Simpson-Yap, S ORCID: 0000-0001-6521-3056 2020 , 'Perceived cognitive impairment is associated with sexual dysfunction in people with multiple sclerosis: a 2.5-year follow-up study of a large international cohort' , Multiple Sclerosis and Related Disorders, vol. 45 , pp. 1-8 , doi: 10.1016/j.msard.2020.102410.

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Abstract

Background: The potential relationship between perceived cognitive impairment (PCI) and sexual dysfunction in multiple sclerosis (MS) has not been studied. Objectives: To explore the relationship between cognitive impairment and sexual dysfunction over 2.5 years in people with MS. Methods: Data were derived from the Health Outcomes and Lifestyle In a Sample of people with Multiple sclerosis (HOLISM) international cohort over 2.5 years' follow-up. Cognitive function and sexual function were assessed by sub-scores of the MS Quality of Life-54. The impact of perceived cognitive impairment on sexual dysfunction was assessed by calculating prevalence ratios (PR) and relative risks (RR) with 95% confidence intervals (CI) using log-binomial regression models. Results: 1958 participants were included at baseline, of whom 555 without perceived cognitive impairment at baseline comprised the longitudinal cohort. The prevalence of perceived cognitive impairment at baseline was 45.6%. At baseline, cognitive impairment was associated with increased frequency of self-reported sexual dysfunction (aPR=1.32, 95% CI: 1.17-1.48). Among the sample without sexual dysfunction at baseline, incident sexual dysfunction was more common among participants with persistent (aRR=1.61, 95% CI: 1.06-3.18) and newly reported cognitive impairment (aRR=1.89, 95% CI: 1.14-3.14). Conclusion: Results suggest PCI may be an independent risk factor for sexual dysfunction in PwMS, which may represent an additional dimension whereby MS may adversely affect quality of life.

Item Type: Article
Authors/Creators:Wu, J and Jelinek, GA and Weiland, T and Hedstrom, AK and Alfredsson, L and Neate, S and De Livera, A and Nag, N and Simpson-Yap, S
Keywords: cognitive impairment, longitudinal study, multiple sclerosis, quality of life, sexual dysfunction
Journal or Publication Title: Multiple Sclerosis and Related Disorders
Publisher: Elsevier BV
ISSN: 2211-0348
DOI / ID Number: 10.1016/j.msard.2020.102410
Copyright Information:

Copyright 2020 Elsevier BV

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