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Does NLRP3 inflammasome and aryl hydrocarbon receptor play an interlinked role in bowel inflammation and colitis-associated colorectal cancer?

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Ngui, IQH, Perera, AP and Eri, R ORCID: 0000-0003-1688-8043 2020 , 'Does NLRP3 inflammasome and aryl hydrocarbon receptor play an interlinked role in bowel inflammation and colitis-associated colorectal cancer?' , Molecules, vol. 25, no. 10 , pp. 1-25 , doi: 10.3390/molecules25102427.

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Abstract

Inflammation is a hallmark in many forms of cancer; with colitis-associated colorectalcancer (CAC) being a progressive intestinal inflammation due to inflammatory bowel disease (IBD).While this is an exemplification of the negatives of inflammation, it is just as crucial to have somedegree of the inflammatory process to maintain a healthy immune system. A pivotal component inthe maintenance of such intestinal homeostasis is the innate immunity component, inflammasomes.Inflammasomes are large, cytosolic protein complexes formed following stimulation of microbial andstress signals that lead to the expression of pro-inflammatory cytokines. The NOD-, LRR- and pyrindomain-containing protein 3 (NLRP3) inflammasome has been extensively studied in part due toits strong association with colitis and CAC. The aryl hydrocarbon receptor (AhR) has recently beenacknowledged for its connection to the immune system aside from its role as an environmental sensor.AhR has been described to play a role in the inhibition of the NLRP3 inflammasome activationpathway. This review will summarise the signalling pathways of both the NLRP3 inflammasomeand AhR; as well as new-found links between these two signalling pathways in intestinal immunityand some potential therapeutic agents that have been found to take advantage of this link in thetreatment of colitis and CAC.

Item Type: Article
Authors/Creators:Ngui, IQH and Perera, AP and Eri, R
Keywords: aryl hydrocarbon receptor, NLRP3 inflammasome, colitis, colon cancer, NF-κB
Journal or Publication Title: Molecules
Publisher: Molecular Diversity Preservation International
ISSN: 1420-3049
DOI / ID Number: 10.3390/molecules25102427
Copyright Information:

Copyright This is an open access article distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited https://creativecommons.org/licenses/by/4.0/

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