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Transcriptomic profiling in fins of Atlantic salmon parasitized with sea lice: evidence for an early imbalance between chalimus-induced immunomodulation and the host’s defense response

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Umasuthan, N, Xue, X, Caballero-Solares, A, Kumar, S, Westcott, JD, Chen, Z, Fast, MD, Skugor, S, Nowak, BF ORCID: 0000-0002-0347-643X, Taylor, RG and Rise, ML 2020 , 'Transcriptomic profiling in fins of Atlantic salmon parasitized with sea lice: evidence for an early imbalance between chalimus-induced immunomodulation and the host’s defense response' , International Journal of Molecular Sciences, vol. 21, no. 7 , pp. 1-45 , doi: 10.3390/ijms21072417.

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Abstract

Parasitic sea lice (e.g., Lepeophtheirus salmonis) cause costly outbreaks in salmon farming. Molecular insights into parasite-induced host responses will provide the basis for improved management strategies. We investigated the early transcriptomic responses in pelvic fins of Atlantic salmon parasitized with chalimus I stage sea lice. Fin samples collected from non-infected (i.e., pre-infected) control (PRE) and at chalimus-attachment sites (ATT) and adjacent to chalimus-attachment sites (ADJ) from infected fish were used in profiling global gene expression using 44K microarrays. We identified 6568 differentially expressed probes (DEPs, FDR p L. salmonis.

Item Type: Article
Authors/Creators:Umasuthan, N and Xue, X and Caballero-Solares, A and Kumar, S and Westcott, JD and Chen, Z and Fast, MD and Skugor, S and Nowak, BF and Taylor, RG and Rise, ML
Keywords: Lepeophtheirus salmonis, chalimus, Salmo salar, fin transcriptome, immunomodulation, anti-sea lice response, 44K microarray, immunogenomics
Journal or Publication Title: International Journal of Molecular Sciences
Publisher: Molecular Diversity Preservation International
ISSN: 1422-0067
DOI / ID Number: 10.3390/ijms21072417
Copyright Information:

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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