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Antibiotics administered within 1 hour to adult emergency department patients screened positive for sepsis: a systematic review

Xantus, G, Allen, P ORCID: 0000-0003-1945-8049, Norman, S and Kanizsai, P 2020 , 'Antibiotics administered within 1 hour to adult emergency department patients screened positive for sepsis: a systematic review' , European Journal of Emergency Medicine, vol. 27, no. 4 , pp. 260-267 , doi: 10.1097/MEJ.0000000000000654.

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Abstract

Objective: The 2018 Surviving Sepsis Campaign update recommended instigating the Sepsis-6 bundle within 1 h; however, the supporting evidence is weak. The objective was to systematically review the literature to determine whether there is mortality benefit (hospital or 28/30-day survival) associated with administration of antibiotics Methods: A systematic review and meta-analysis were conducted. Embase, CINAHL, Medline, Pubmed, Cochrane Library and grey literature were searched for articles published between 2012 and 2019.Results: From 232 identified articles, seven met the inclusion criteria. Due to the small number of articles that fit the inclusion criteria and the considerable heterogeneity (I = 92.6%, P Conclusion: There is equivocal evidence of in-hospital or 28/30-day survival benefit associated with antibiotics administered ≤1 h after presentation to the ED for patients who screened positive for sepsis. Further research is needed to identify the exact patient group, which would truly benefit from initiation of antibiotics

Item Type: Article
Authors/Creators:Xantus, G and Allen, P and Norman, S and Kanizsai, P
Keywords: sepsis, antibiotics, early administration, emergency department, systematic review
Journal or Publication Title: European Journal of Emergency Medicine
Publisher: Lippincott Williams & Wilkins
ISSN: 0969-9546
DOI / ID Number: 10.1097/MEJ.0000000000000654
Copyright Information:

Copyright 2020 Wolters Kluwer Health, Inc.

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