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Treatment algorithm for hyaluronic acid-related complication based on a systematic review of case reports, case series, and clinical experience


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Abstract
Study Design: Systematic review of hyaluronic acid (HA)-related complications.Objective: To systematically review all available literature including case reports and case series to identify a pattern forthe management of vascular compromise resulting in facial skin ischemia and ocular manifestations following HA injection.Methods: This review was based on a systematic search of 3 electronic databases PubMed, CINAHL, and Scopus for allavailable literature including case series and case reports from database inception to July 2019. Only a total of 52 casereports/series were eligible for review and included 107 patients.Results: The reviewed literature available was comprised from case reports/series and indicated that management ofboth impending skin necrosis and visual disturbances is variable with no repetitive pattern of action. Yet, successfulmanagement is time dependent as early interventions stopped progression and, in some cases, even reversed adverseeffects.Conclusion: Results found no universal protocol for achieving optimal results for adverse effects and as such, we presenta step-by-step algorithm for the emergency management of complications following HA injection.
Item Type: | Article |
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Authors/Creators: | Aviv, U and Haik, J and Weiss, N and Berl, A and Ofir, H and Nardini, G and Cleary, M and Kornhaber, R and Harats, M |
Keywords: | hyaluronic acid, complications, treatment algorithm, systematic review |
Journal or Publication Title: | Craniomaxillofacial Trauma & Reconstruction |
Publisher: | Sage Publications, Inc. |
ISSN: | 1943-3875 |
DOI / ID Number: | https://doi.org/10.1177/1943387520952687 |
Copyright Information: | Copyright The Author(s) 2020 |
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