PDF (Post print) 140821 - Change...pdf | Document not available for request/download Full text restricted until 3 September 2021.

Abstract

Background: Little is known about the change in prevalence of comorbidities during the disease course of people with multiple sclerosis (MS) and whether the prevalences vary by MS onset type. Objective: To calculate the change in prevalence of comorbidities between symptom onset and the time of study, to compare the prevalences of comorbidities with those in the Australian population at the time of study and to examine onset-type differences. Methods: Comorbidity data from 1518 participants of the Australian MS Longitudinal Study and Australian population comparator data (2014-2015 National Health Survey) were used. The change in prevalence between time points and prevalence ratios (PR) at the time of study (crude, age and sex adjusted, and stratified by onset type) was calculated. Results: Comorbidities were common, and those with the largest increases in prevalence between MS symptom onset and the time of study were depression (+ 26.9%), anxiety (+ 23.1%), hypertension (+ 21.9%), elevated cholesterol (+ 16.3%), osteoarthritis (+ 17.1%), eye diseases (+ 11.6%), osteoporosis (+ 10.9%) and cancer (+ 10.3%). Compared to the general population and after age and sex adjustment, participants had a significantly higher prevalence for 14/19 comorbidities at the time of study. The associations were strongest for anaemia, cancer (both PR > 4.00), anxiety, depression, migraine (all PR > 3.00), psoriasis and epilepsy (both PR > 2.00). No significant differences were seen by onset type. Conclusion: Comorbidities are common at MS symptom onset and increase with MS duration. Having MS may thus contribute to accrual of comorbidities. This emphasises the importance of optimal screening for and management of comorbidities in early MS and throughout the disease course.

Item Type:	Article
Authors/Creators:	Lo, LMP and Taylor, BV and Winzenberg, T and Palmer, AJ and Blizzard, L and van der Mei, I
Keywords:	comorbidity, MS onset type, multiple sclerosis, prevalence, prevalence ratio
Journal or Publication Title:	Journal of Neurology
Publisher:	Dr Dietrich Steinkopff Verlag
ISSN:	0340-5354
DOI / ID Number:	10.1007/s00415-020-10194-x
Copyright Information:	© Springer-Verlag GmbH Germany, part of Springer Nature 2020. Post-prints are subject to Springer Nature re-use terms
Related URLs:	UTAS Profile: Taylor, BV Google Scholar: Winzenberg, T UTAS Profile: Winzenberg, T UTAS Profile: Palmer, AJ UTAS Profile: Blizzard, L Google Scholar: van der Mei, I UTAS Profile: van der Mei, I
Item Statistics:	View statistics for this item

Actions (login required)

Item Control Page