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Abstract

Background: Little is known about the relative contribution of comorbidities in predicting the health-related quality of life (HRQoL) of people with Multiple Sclerosis (PwMS). Objective: To determine the associations between the number of and individual comorbidities and HRQoL and estimate the relative contribution of different comorbidities on HRQoL. Methods: Cross-sectional analysis of data on self-reported presence of 30 comorbidities and HRQoL from the Australian MS Longitudinal Study (AMSLS) participants (n = 902). HRQoL was measured using the Assessment of Quality of Life-8 Dimensions (AQoL-8D). Linear regression and general dominance analysis were used. Results: Higher number of comorbidities was associated with lower HRQoL (p trend p Conclusion: Comorbidities potentially make important contributions to HRQoL in PwMS. Our findings highlight groups of and individual comorbidities that could provide the largest benefits for the HRQoL of PwMS if they were targeted for prevention, early detection, and optimal treatment.

Item Type:	Article
Authors/Creators:	Lo, LMP and Taylor, BV and Winzenberg, T and Palmer, AJ and Blizzard, L and Ahmad, H and Hussain, MA and van der Mei, I
Keywords:	AQoL-8D, comorbidity, general dominance analysis, multiple sclerosis, quality of life, relative contribution
Journal or Publication Title:	Journal of Neurology
Publisher:	Dr Dietrich Steinkopff Verlag
ISSN:	0340-5354
DOI / ID Number:	https://doi.org/10.1007/s00415-020-10195-w
Copyright Information:	© Springer-Verlag GmbH Germany, part of Springer Nature 2020. Post-prints are subject to Springer Nature re-use terms
Related URLs:	UTAS Profile: Taylor, BV Google Scholar: Winzenberg, T UTAS Profile: Winzenberg, T UTAS Profile: Palmer, AJ UTAS Profile: Blizzard, L Google Scholar: van der Mei, I UTAS Profile: van der Mei, I
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