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Ambulatory oxygen in fibrotic interstitial lung disease: a pilot, randomized, triple-blinded, sham-controlled trial

Khor, YH, Holland, AE, Goh, NSL, Miller, BR, Vlahos, R, Bozinovski, S, Lahham, A ORCID: 0000-0003-2090-0746, Glaspole, I and McDonald, CF 2020 , 'Ambulatory oxygen in fibrotic interstitial lung disease: a pilot, randomized, triple-blinded, sham-controlled trial' , Chest, vol. 158, no. 1 , pp. 234-244 , doi: 10.1016/j.chest.2020.01.049.

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Abstract

Background: Despite a lack of evidence, ambulatory oxygen therapy is frequently prescribed for patients with interstitial lung disease (ILD) and exertional desaturation. Patients often prefer portable oxygen concentrators to oxygen cylinders. This study aimed to examine the feasibility of conducting a clinical trial of ambulatory oxygen delivered via portable concentrators in patients with ILD. Research question: Is it feasible to conduct a clinical trial of ambulatory oxygen delivered via portable concentrators in patients with ILD? Study design and methods: In this randomized, triple-blinded, sham-controlled trial, 30 participants with ILD and isolated exertional desaturation to Results: Study recruitment was completed within 18 months, with six withdrawals. Participant blinding was successful, with the Bang's Blinding Index being 0 (95% CI, -0.40 to 0.40) for the oxygen group and 0 (95% CI, -0.42 to 0.42) for the sham group. No significant difference in 6MWD was seen between groups at week 12 (mean difference of -34 m [95% CI, -105 to 36], P = .34). For secondary outcomes, compared with the sham group, the oxygen group had a significantly higher Leicester Cough Questionnaire psychological domain score, indicating better cough-related quality of life (mean difference of 0.9 [95% CI, 0.2 to 1.6], P = .01), but a shorter duration of moderate-to-vigorous activities (mean difference of -135 [95% CI, -267 to -3], P = .04) at week 12. Interpretation: Based on the results of this pilot study, a definitive randomized controlled trial with a longer intervention duration is warranted to clarify therapeutic impacts of ambulatory oxygen in patients with ILD.

Item Type: Article
Authors/Creators:Khor, YH and Holland, AE and Goh, NSL and Miller, BR and Vlahos, R and Bozinovski, S and Lahham, A and Glaspole, I and McDonald, CF
Keywords: exertional hypoxemia, idiopathic pulmonary fibrosis, interstitial lung disease, oxygen, pulmonary fibrosis
Journal or Publication Title: Chest
Publisher: Amer Coll Chest Physicians
ISSN: 0012-3692
DOI / ID Number: 10.1016/j.chest.2020.01.049
Copyright Information:

Copyright 2020 American College of Chest Physicians

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