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Do NSAIDs Affect the Progression of Osteoarthritis?


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Ding, C 2002 , 'Do NSAIDs Affect the Progression of Osteoarthritis?' , Inflammation, vol. 26, no. 3 , pp. 139-142 , doi: 10.1023/A:1015504632021.

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Abstract—NSAIDs are widely used to alleviate the symptoms of OA. It remains controversial as to
what effects these agents have on the progression of OA. In vitro studies showed several types of
NSAIDs (e.g., sodium salicylate, indomethacin) inhibited the synthesis of cartilage matrix component,
but some types of NSAIDs (e.g., aceclofenac, meloxicam, nimesulide) increased the matrix
component synthesis and protected the chondrocytes against apoptosis, while others (e.g., piroxicam)
had no effects. Studies in animal models verified that NSAIDs had favourable or detrimental
action on OA progression, even the same NSAID (e.g., naproxen, tiaprofenic acid) had reverse
effects on articular cartilage in different studies. Preliminary clinical trials revealed some NSAIDs
such as indomethacin had a negative influence on joint structure, other NSAIDs such as diclofenac
and naproxen had no acceleration of radiographic damage to OA within 2-years of treatment. So
far, there are no convincing data to show the widely used NSAIDs and recommended selective
COX-2 inhibitor have favourable effects on cartilage. Therefore, it is necessary and valuable to
clarify the effects of these NSAIDs on cartilage in patients with OA using validated non-invasive
methods such as MRI.

Item Type: Article
Authors/Creators:Ding, C
Keywords: NSAIDs - Osteoarthritis - Progression - cartilage
Journal or Publication Title: Inflammation
ISSN: 0360-3997
DOI / ID Number: 10.1023/A:1015504632021
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