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Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems

Justice, AE, Chittoor, G, Gondalia, R, Melton, PE ORCID: 0000-0003-4026-2964, Lim, E, Grove, ML, Whitsel, EA, Liu, C-T, Cupples, LA, Fernandez-Rhodes, L, Guan, W, Bressler, J, Fornage, M, Boerwinkle, E, Li, Y, Demerath, E, Heard-Costa, N, Levy, D, Stewart, JD, Baccarelli, A, Hou, L, Conneely, K, Mori, MA, Beilin, LJ, Huang, R-C, Gordon-Larsen, P, Howard, AG and North, KE 2020 , 'Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems' , Epigenomics, vol. 12, no. 17 , pp. 1483-1499 , doi: 10.2217/epi-2019-0276.

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Abstract

Aim: We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study. Materials & methods: We validated significantly associated cytosine-phosphate-guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820).Results & conclusion: We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations near TXNIP, ADCY7, SREBF1 and RAP1GAP2 that had not previously been associated with obesity-related traits.

Item Type: Article
Authors/Creators:Justice, AE and Chittoor, G and Gondalia, R and Melton, PE and Lim, E and Grove, ML and Whitsel, EA and Liu, C-T and Cupples, LA and Fernandez-Rhodes, L and Guan, W and Bressler, J and Fornage, M and Boerwinkle, E and Li, Y and Demerath, E and Heard-Costa, N and Levy, D and Stewart, JD and Baccarelli, A and Hou, L and Conneely, K and Mori, MA and Beilin, LJ and Huang, R-C and Gordon-Larsen, P and Howard, AG and North, KE
Keywords: DNA methylation, TXNIP, ancestrally diverse, body fat distribution, cardiometabolic disease, central adiposity, methylome-wide association study, waist circumference, waist-to-height ratio, waist-to-hip ratio
Journal or Publication Title: Epigenomics
Publisher: Future Medicine Ltd.
ISSN: 1750-1911
DOI / ID Number: 10.2217/epi-2019-0276
Copyright Information:

Copyright 2020 Future Medicine Ltd.

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