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Excess pressure as an analogue of blood flow velocity

Armstrong, MK, Schultz, MG ORCID: 0000-0003-3458-1811, Hughes, AD, Picone, DS ORCID: 0000-0002-4760-1634, Black, JA, Dwyer, N, Roberts-Thomson, P and Sharman, JE ORCID: 0000-0003-2792-0811 2020 , 'Excess pressure as an analogue of blood flow velocity' , Journal of Hypertension, vol. 38 , pp. 1-7 , doi: 10.1097/HJH.0000000000002662.

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Abstract

Introduction: Derivation of blood flow velocity from a blood pressure waveform is a novel technique, which could have potential clinical importance. Excess pressure, calculated from the blood pressure waveform via the reservoir-excess pressure model, is purported to be an analogue of blood flow velocity but this has never been examined in detail, which was the aim of this study. Methods: Intra-arterial blood pressure was measured sequentially at the brachial and radial arteries via fluid-filled catheter simultaneously with blood flow velocity waveforms recorded via Doppler ultrasound on the contralateral arm (n = 98, aged 61 ± 10 years, 72% men). Excess pressure was derived from intra-arterial blood pressure waveforms using pressure-only reservoir-excess pressure analysis. Results: Brachial and radial blood flow velocity waveform morphology were closely approximated by excess pressure derived from their respective sites of measurement (median cross-correlation coefficient r = 0.96 and r = 0.95 for brachial and radial comparisons, respectively). In frequency analyses, coherence between blood flow velocity and excess pressure was similar for brachial and radial artery comparisons (brachial and radial median coherence = 0.93 and 0.92, respectively). Brachial and radial blood flow velocity pulse heights were correlated with their respective excess pressure pulse heights (r = 0.53, P r = 0.43, P Conclusion: Excess pressure is an analogue of blood flow velocity, thus affording the opportunity to derive potentially important information related to arterial blood flow using only the blood pressure waveform.

Item Type: Article
Authors/Creators:Armstrong, MK and Schultz, MG and Hughes, AD and Picone, DS and Black, JA and Dwyer, N and Roberts-Thomson, P and Sharman, JE
Keywords: hemodynamics, invasive, pulse wave analysis
Journal or Publication Title: Journal of Hypertension
Publisher: Lippincott Williams & Wilkins
ISSN: 0263-6352
DOI / ID Number: 10.1097/HJH.0000000000002662
Copyright Information:

Copyright © 2020 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited.

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