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Feelings of depression, pain and walking difficulties have the largest impact on the quality of life of people with multiple sclerosis, irrespective of clinical phenotype

Zhang, Y, Taylor, BV, Simpson Jr, S ORCID: 0000-0001-6521-3056, Blizzard, L ORCID: 0000-0002-9541-6943, Campbell, JA ORCID: 0000-0002-1820-6758, Palmer, AJ ORCID: 0000-0002-9703-7891 and van der Mei, I ORCID: 0000-0001-9009-7472 2020 , 'Feelings of depression, pain and walking difficulties have the largest impact on the quality of life of people with multiple sclerosis, irrespective of clinical phenotype' , Multiple Sclerosis Journal, no. Septem , pp. 1-14 , doi: 10.1177/1352458520958369.

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Abstract

Background: The symptoms that have the largest impact on health-related quality of life (HRQoL) in people with multiple sclerosis (MS) may vary by MS phenotype (relapsing-remitting MS (RRMS), secondary progressive MS (SPMS) and primary progressive MS (PPMS)). Knowing these symptoms assists in symptom management. Objective: To examine the associations between 13 common MS symptoms and HRQoL in the total sample and stratified by MS phenotype. Method: The study included 1985 participants. HRQoL was measured with two multi-attribute utility instruments: assessment of quality of life with eight dimensions (AQoL-8D) and European quality of life with five dimensions and five levels for each dimension (EQ-5D-5L). Multivariable linear regression was used to identify the symptoms that had the largest impact on the HRQoLs. Results: Feelings of depression, pain, fatigue, and feelings of anxiety were most strongly associated with AQoL-8D and EQ-5D-5L. Walking difficulties additionally contributed to reduced EQ-5D-5L. The strongest single predictors in the multivariable analyses were feelings of depression or pain for AQoL-8D and walking difficulties for EQ-5D-5L, irrespective of MS phenotype. Conclusion: The strongest single predictors for the AQoL-8D and EQ-5D-5L were feelings of depression, pain and walking difficulties, irrespective of MS phenotype. Reducing these symptoms may have the largest impact on improving HRQoL in all MS phenotypes of people with MS.

Item Type: Article
Authors/Creators:Zhang, Y and Taylor, BV and Simpson Jr, S and Blizzard, L and Campbell, JA and Palmer, AJ and van der Mei, I
Keywords: European quality of life with five dimensions and five levels for each dimension, multiple sclerosis, assessment of quality of life with eight dimensions, depression, health-related quality of life, pain, symptoms, walking difficulties
Journal or Publication Title: Multiple Sclerosis Journal
Publisher: Arnold
ISSN: 1352-4585
DOI / ID Number: 10.1177/1352458520958369
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Copyright 2020 The Authors

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