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Anthocyanins attenuate vascular and inflammatory responses to a high fat high energy meal challenge in overweight older adults: A cross-over, randomized, double-blind clinical trial

do Rosario, VA, Chang, C, Spencer, J, Alahakone, T, Roodenrys, S, Francois, M, Weston-Green, K, Holzel, N, Nichols, DS ORCID: 0000-0002-8066-3132, Kent, K ORCID: 0000-0002-5330-7044, Williams, D, Wright, IMR and Charlton, K 2020 , 'Anthocyanins attenuate vascular and inflammatory responses to a high fat high energy meal challenge in overweight older adults: A cross-over, randomized, double-blind clinical trial' , Clinical Nutrition , pp. 1-11 , doi: 10.1016/j.clnu.2020.09.041.

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Abstract

Background & aims: Postprandial metabolic imbalances are important indicators of later developing cardiovascular disease (CVD). This study investigated the effects of food anthocyanins on vascular and microvascular function, and CVD associated biomarkers following a high fat high energy (HFHE) meal challenge in overweight older adults.Methods: Sixteen subjects (13 female, 3 male, mean age 65.9 SD 6.0 and body mass index 30.6 kg/m2 SD 3.9) participated in a crossover, randomized, controlled, double-blind clinical trial (registered under Australian New Zealand Clinical Trials Registry, identifier no. ACTRN12620000437965). Participants consumed a HFHE meal with a 250 mL dose of either intervention (anthocyanins-rich Queen Garnet Plum) or control (apricot) juice. Blood samples and blood pressure measures were collected at baseline, 2 h and 4 h following the HFHE meal. Vascular and microvascular function were evaluated at baseline and 2 h after the HFHE meal.Results:Participants had a higher 2 h postprandial flow-mediated dilatation (+1.14%) and a higher microvascular post-occlusive reactive hyperaemia (+0.10 perfusion units per mmHg) when allocated to the anthocyanin compared to the control arm (P = 0.019 and P = 0.049, respectively). C-reactive protein was lower 4 h postprandially in the anthocyanins (1.80 mg/L, IQR 0.90) vs control arm (2.30 mg/L, IQR 1.95) (P = 0.026), accompanied by a trend for lower concentrations of interleukin-6 (P = 0.075). No significant postprandial differences were observed between treatments for blood pressure, triacylglycerol, total cholesterol, serum derivatives of reactive oxidative metabolites, tumor necrosis factor alpha, interleukin-1 beta, or maximum microvascular perfusion following iontophoresis of acetylcholine.Conclusion: Fruit-based anthocyanins attenuated the potential postprandial detrimental effects of a HFHE challenge on parameters of vascular and microvascular function, and inflammatory biomarkers in overweight older adults. Anthocyanins may reduce cardiovascular risk associated with endothelial dysfunction and inflammatory responses to a typical high fat 'Western' meal. Further studies are required to better elucidate the clinical implications of postprandial biomarkers of CVD.

Item Type: Article
Authors/Creators:do Rosario, VA and Chang, C and Spencer, J and Alahakone, T and Roodenrys, S and Francois, M and Weston-Green, K and Holzel, N and Nichols, DS and Kent, K and Williams, D and Wright, IMR and Charlton, K
Keywords: anthocyanin, flavonoid, inflammation, endothelium, vascular
Journal or Publication Title: Clinical Nutrition
Publisher: Churchill Livingstone
ISSN: 0261-5614
DOI / ID Number: 10.1016/j.clnu.2020.09.041
Copyright Information:

Copyright 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism

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