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The rise of electronic nicotine delivery systems and the emergence of electronic-cigarette-driven disease

McAlinden, KD, Eapen, MS ORCID: 0000-0003-0570-7059, Lu, W, Sharma, P and Sohal, SS ORCID: 0000-0001-9627-6498 2020 , 'The rise of electronic nicotine delivery systems and the emergence of electronic-cigarette-driven disease' , American Journal of Physiology: Lung Cellular and Molecular Physiology, vol. 19, no. 4 , L585-L595 , doi:

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In 2019, the United States experienced the emergence of the vaping-associated lung injury (VALI) epidemic. Vaping is now known to result in the development and progression of severe lung disease in the young and healthy. Lack of regulation on electronic cigarettes in the United States has resulted in over 2,000 patients and 68 deaths. We examine the clinical representation of VALI and the delve into the scientific evidence of how deadly exposure to electronic cigarettes can be. E-cigarette vapor is shown to affect numerous cellular processes, cellular metabolism, and cause DNA damage (which has implications for cancer). E-cigarette use is associated with a higher risk of developing crippling lung conditions such as chronic obstructive pulmonary disease (COPD), which would develop several years from now, increasing the already existent smoking-related burden. The role of vaping and virus susceptibility is yet to be determined; however, vaping can increase the virulence and inflammatory potential of several lung pathogens and is also linked to an increased risk of pneumonia. As it has emerged for cigarette smoking, great caution should also be given to vaping in relation to SARS-CoV-2 infection and the COVID-19 pandemic. Sadly, e-cigarettes are continually promoted and perceived as a safer alternative to cigarette smoking. E-cigarettes and their modifiable nature are harmful, as the lungs are not designed for the chronic inhalation of e-cigarette vapor. It is of interest that e-cigarettes have been shown to be of no help with smoking cessation. A true danger lies in vaping, which, if ignored, will lead to disastrous future costs.

Item Type: Article
Authors/Creators:McAlinden, KD and Eapen, MS and Lu, W and Sharma, P and Sohal, SS
Keywords: vaping, COVID-19, SARS-CoV-2, electronic cigarettes, IQOS, COPD, epithelium, fibrosis, EMT, Cancer, ICS
Journal or Publication Title: American Journal of Physiology: Lung Cellular and Molecular Physiology
Publisher: Amer Physiological Soc
ISSN: 1040-0605
DOI / ID Number:
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Copyright © 2020 the American Physiological Society

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