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Diagnostic approaches in COVID-19: clinical updates

Asrani, P, Eapen, MS ORCID: 0000-0003-0570-7059, Chia, C, Haug, G, Weber, HC, Hassan, Md Imtaiyaz and Sohal, SS ORCID: 0000-0001-9627-6498 2020 , 'Diagnostic approaches in COVID-19: clinical updates' , Expert Review of Respiratory Medicine , pp. 1-16 , doi: 10.1080/17476348.2021.1823833.

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Introduction: COVID-19 is a recent emerging pandemic whose prognosis is still unclear. Diagnostictools are the main players that not only indicate a possible infection but can further restrict thetransmission and can determine the extent to which disease progression would occur.Areas covered: In this paper, we have performed a narrative and critical review on different technology-based diagnostic strategies such as molecular approaches including real-time reverse transcriptasePCR, serological testing through enzyme-linked immunosorbent assay, laboratory and point of caredevices, radiology-based detection through computed tomography and chest X-ray, and viral cellcultures on Vero E6 cell lines are discussed in detail to address COVID-19. This review further providesan overview of emergency use authorized immunodiagnostic and molecular diagnostic kits and POCdevices by FDA for timely and efficient conduction of diagnostic tests. The majority of the literaturecited in this paper is collected from guidelines on protocols and other considerations on diagnosticstrategies of COVID-19 issued by WHO, CDC, and FDA under emergency authorization.Expert opinion: Such information holds importance to the health professionals in conducting error-freediagnostic tests and researches in producing better clinical strategies by addressing the limitationsassociated with the available methods.

Item Type: Article
Authors/Creators:Asrani, P and Eapen, MS and Chia, C and Haug, G and Weber, HC and Hassan, Md Imtaiyaz and Sohal, SS
Keywords: COVID-19, SARS-CoV-2, immunodiagnostics, point of care, serological testing, radiology, viral cell culture, rRT-PCR
Journal or Publication Title: Expert Review of Respiratory Medicine
Publisher: Taylor & Francis
ISSN: 1747-6348
DOI / ID Number: 10.1080/17476348.2021.1823833
Copyright Information:

Copyright 2020 Informa UK Limited, trading as Taylor & Francis Group

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