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Effects of vitamin D supplementation on disabling foot pain in patients with symptomatic knee osteoarthritis


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Tu, L, Zheng, S, Cicuttini, F, Jin, X, Han, W, Zhu, Z, Antony, B ORCID: 0000-0001-8704-6084, Winzenberg, T ORCID: 0000-0002-4112-3491, Jones, G ORCID: 0000-0002-9814-0006, Gu, J, Wluka, AE and Ding, C ORCID: 0000-0002-9479-730X 2020 , 'Effects of vitamin D supplementation on disabling foot pain in patients with symptomatic knee osteoarthritis' , Arthritis Care & Research, no. July , pp. 1-26 , doi: 10.1002/acr.24371.

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Objectives: This study aims to determine whether vitamin D supplementation or maintaining sufficient vitamin D level reduces foot pain over two years in patients with symptomatic knee OA. Methods: A post hoc study was conducted from a randomized double-blind placebo-controlled trial named the VItamin D Effect on Osteoarthritis (VIDEO) study. Symptomatic knee OA patients with serum 25-hydroxyvitamin D levels between 12.5 nmol/L to 60 nmol/L were included and randomly allocated to either monthly vitamin D3 or placebo treatment (1:1) for 2 years. Manchester Foot Pain and Disability Index (MFPDI) was used to evaluate foot pain and Disabling foot pain was defined as at least one of the 10 functional limitation items (items 1-9,11) being documented as on 'most/every day(s)' in the last month. A repeated-measure mixed effect model was used to analyze the change of MFPDI scores between groups adjusting for potential confounders.Results: A total of 413 patients with a mean age of 63.2 years (49.7% males) were enrolled and 340 completed the study. The mean MFPDI score was 22.8±7.3, with 23.7% participants having disabling foot pain at baseline. There were significant differences in MFPDI scores change between groups over 2 years, with more improvements in vitamin D group than in placebo group (-0.03 vs. 1.30, P=0.013) and more improvement in those maintaining sufficient vitamin D levels (n=226) than those who did not (n=114) (-0.09 vs. 2.19, P=0.001). Conclusion: Vitamin D supplementation and maintenance of sufficient vitamin D levels may improve foot pain in those with knee OA.

Item Type: Article
Authors/Creators:Tu, L and Zheng, S and Cicuttini, F and Jin, X and Han, W and Zhu, Z and Antony, B and Winzenberg, T and Jones, G and Gu, J and Wluka, AE and Ding, C
Keywords: osteoarthritis, foot pain, vitamin D
Journal or Publication Title: Arthritis Care & Research
Publisher: John Wiley & Sons, Inc.
ISSN: 2151-464X
DOI / ID Number: 10.1002/acr.24371
Copyright Information:

This is the peer reviewed version of the following article, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

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