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Dopamine, endocannabinoids and their interaction in fear extinction and negative affect in PTSD

Ney, LJ, Akhurst, J, Bruno, R ORCID: 0000-0001-6673-833X, Laing, PAF, Matthews, A ORCID: 0000-0003-2961-9125 and Felmingham, KL 2020 , 'Dopamine, endocannabinoids and their interaction in fear extinction and negative affect in PTSD' , Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 105 , pp. 1-17 , doi: 10.1016/j.pnpbp.2020.110118.

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Abstract

There currently exist few frameworks for common neurobiology between reexperiencing and negative cognitions and mood symptoms of PTSD. Adopting a dopaminergic framework for PTSD unites many aspects of unique symptom clusters, and this approach also links PTSD symptomology to common comorbidities with a common neurobiological deficiency. Here we review the dopamine literature and incorporate it with a growing field of research that describes both the contribution of endocannabinoids to fear extinction and PTSD, as well as the interactions between dopaminergic and endocannabinoid systems underlying this disorder. Based on current evidence, we outline an early, preliminary model that links re-experiencing and negative cognitions and mood in PTSD by invoking the interaction between endocannabinoid and dopaminergic signalling in the brain. These interactions between PTSD, dopamine and endocannabinoids may have implications for future therapies for treatment-resistant and comorbid PTSD patients.

Item Type: Article
Authors/Creators:Ney, LJ and Akhurst, J and Bruno, R and Laing, PAF and Matthews, A and Felmingham, KL
Keywords: dopamine, posttraumatic stress disorder, endocannabinoids, PTSD, comorbidity
Journal or Publication Title: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher: Pergamon-Elsevier Science Ltd
ISSN: 0278-5846
DOI / ID Number: 10.1016/j.pnpbp.2020.110118
Copyright Information:

Copyright 2020 Elsevier Inc.

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