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Evaluating health related quality of life in older people at risk of osteoporotic fracture: a head-to-head comparison of the EQ-5D-5L and AQoL-6D

Si, L, Tu, L, Xie, Y, Chen, G, Hiligsmann, M, Yang, M, Zhang, Yanli, Zhang, X, Jiang, Y, Wei, Q, Gu, J and Palmer, AJ ORCID: 0000-0002-9703-7891 2020 , 'Evaluating health related quality of life in older people at risk of osteoporotic fracture: a head-to-head comparison of the EQ-5D-5L and AQoL-6D' , Social Indicators Research , pp. 1-16 , doi: 10.1007/s11205-020-02414-8.

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We aimed to conduct a head-to-head comparison of the five-level version of the EuroQolfive-dimensional questionnaire (EQ-5D-5L) and the Assessment of Quality of Life-6D(AQoL-6D) in measuring health-related quality of life (HRQoL) of older people at riskof osteoporotic fracture. Participants (n = 291) were recruited from the Third AffiliatedHospital of Sun Yat-Sen University. Study participants were asked to complete the EQ-5D-5L and the AQoL-6D and the results were converted to health-state utilities (HSUs)using population-specific scoring algorithms. The agreement among HSUs was evaluatedusing the intraclass correlation coefficient and illustrated using Bland–Altman plots. Theminimally important difference (MID) for the EQ-5D and AQoL was set at 0.074 and 0.06.Information on socio-demographic background, socio-economic status and clinical riskfactors in FRAX® was collected. Nonparametric statistics were used to explore the known groupvalidity measured by fracture risk. Mean (median) EQ-5D-5L and AQoL-6D HSUswere 0.73(0.83) and 0.74(0.79) for the study population. The EQ-5D-5L and the AQoL-6DHSUs strongly agreed and the HSU difference reached the MID level in both instruments.While a decreasing trend of AQoL-6D utilities was observed with worsening bone mineraldensity, EQ-5D-5L HSUs were similar in individuals with normal and osteopenic bonemineral densities. The AQoL-6D was also effective for measuring difference in independentliving, relationships, mental health, coping and pain. Both instruments showed goodknown-group validity. The EQ-5D-5L and AQoL-6D are all valid measures for older peopleat risk of osteoporotic fracture.

Item Type: Article
Authors/Creators:Si, L and Tu, L and Xie, Y and Chen, G and Hiligsmann, M and Yang, M and Zhang, Yanli and Zhang, X and Jiang, Y and Wei, Q and Gu, J and Palmer, AJ
Keywords: health-related quality-of-life, EQ-5D, assessment of quality of life, Chinese, osteoporosis
Journal or Publication Title: Social Indicators Research
Publisher: Kluwer Academic Publ
ISSN: 0303-8300
DOI / ID Number: 10.1007/s11205-020-02414-8
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Copyright 2020 Springer Nature B.V.

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