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Abstract

Background: Co-prescribing medications that can interact with direct-acting oral anticoagulants (DOACs) may decrease their safety and efficacy. The aim of this study was to examine the co-prescribing of such medications with DOACs using the Australian national general practice dataset, MedicineInsight, over a five-year period. Methods: We performed five sequential cross-sectional analyses in patients with atrial fibrillation (AF) and a recorded DOAC prescription. Patients were defined as having a drug interaction if they had a recorded prescription of an interacting medication while they had had a recorded prescription of DOAC in the previous six months. The sample size for the cross-sectional analyses ranged from 5333 in 2014 to 19,196 in 2018. Results: The proportion of patients who had potential drug interactions with a DOAC decreased from 45.9% (95% confidence interval (CI) 44.6%–47.4%) in 2014 to 39.9% (95% CI 39.2%–40.6%) in 2018, p for trend Conclusions: Overall, potential drug interactions with DOACs have decreased slightly over the last five years; however, the rate of possible interaction with SSRIs/SNRIs has remained relatively unchanged and warrants awareness-raising amongst prescribers.

Item Type:	Article
Authors/Creators:	Bezabhe, WM and Bereznicki, LR and Radford, J and Wimmer, BC and Salahudeen, MS and Bindoff, I and Garrahy, E and Peterson, GM
Keywords:	atrial fibrillation, direct-acting oral anticoagulants, drug–drug interactions, primary care
Journal or Publication Title:	Journal of Clinical Medicine
Publisher:	M D P I AG
ISSN:	2077-0383
DOI / ID Number:	10.3390/jcm9113568
Copyright Information:	Copyright 2020 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Related URLs:	Google Scholar: Bezabhe, WM Google Scholar: Bereznicki, LR UTAS Profile: Bereznicki, LR Google Scholar: Radford, J UTAS Profile: Radford, J UTAS Profile: Wimmer, BC Google Scholar: Salahudeen, MS Google Scholar: Bindoff, I UTAS Profile: Bindoff, I UTAS Profile: Peterson, GM
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