Open Access Repository

Sex-differential impact of human cytomegalovirus infection on in vitro reactivity to toll-like receptor 2, 4 and 7/8 stimulation in Gambian infants

Downloads

Downloads per month over past year

Cox, M, Adetifa, JU, Noho-Konteh, F, Sanyang, LC, Drammeh, A, Plebanski, M, Whittle, HC, Rowland-Jones, SL, Robertson, IK and Flanagan, KL 2020 , 'Sex-differential impact of human cytomegalovirus infection on in vitro reactivity to toll-like receptor 2, 4 and 7/8 stimulation in Gambian infants' , Vaccines , pp. 1-16 , doi: 10.3390/vaccines8030407.

[img]
Preview
PDF
141862 - sex di...pdf | Download (719kB)

| Preview

Abstract

Human cytomegalovirus (HCMV) infection rates approach 100% by the first year of lifein low-income countries. It is not known if this drives changes to innate immunity in early life andthereby altered immune reactivity to infections and vaccines. Given the panoply of sex differences inimmunity, it is feasible that any immunological effects of HCMV would differ in males and females.We analysed ex vivo innate cytokine responses to a panel of toll-like receptor (TLR) ligands in 108nine-month-old Gambian males and females participating in a vaccine trial. We found evidencethat HCMV suppressed reactivity to TLR2 and TLR7/8 stimulation in females but not males. Thisis likely to contribute to sex differences in responses to infections and vaccines in early life and hasimplications for the development of TLR ligands as vaccine adjuvants. Development of an effectiveHCMV vaccine would be able to circumvent some of these potentially negative effects of HCMVinfection in childhood.

Item Type: Article
Authors/Creators:Cox, M and Adetifa, JU and Noho-Konteh, F and Sanyang, LC and Drammeh, A and Plebanski, M and Whittle, HC and Rowland-Jones, SL and Robertson, IK and Flanagan, KL
Keywords: human cytomegalovirus, human infants, innate immunity, sex differences, vaccination, toll-like receptor, adjuvants, cytokines
Journal or Publication Title: Vaccines
Publisher: MDPI AG
ISSN: 2076-393X
DOI / ID Number: 10.3390/vaccines8030407
Copyright Information:

Copyright 2020 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page
TOP