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Abstract

Objectives: Intestinal colonization by ESBL Escherichia coli and its association with community-acquired MDRinfections is of great concern. This review determined the worldwide prevalence of human faecal ESBL E. coli carriage and its trend in the community over the past two decades.Methods: A systematic literature search was conducted using PubMed, EMBASE and Google Scholar to retrievearticles published between 1 January 2000 and 13 February 2020 that contained data on the prevalence of faecal carriage of ESBL E. coli among healthy individuals. A cumulative (for the whole period) meta-analysis wasused to estimate the global and regional pooled prevalence rates. Articles were grouped into study periods of3 years, and subgroup meta-analyses were undertaken to examine the global pooled prevalence over time.Results: Sixty-two articles covering 29 872 healthy persons were included in this meta-analysis. The cumulative(2003–18) global pooled prevalence of ESBL E. coli intestinal carriage in the community was 16.5% (95% CI14.3%–18.7%; P Conclusions: Globally, an 8-fold increase in the intestinal carriage rate of ESBL E. coli in the community hasoccurred over the past two decades. Prevention of its spread may require new therapeutic and public healthstrategies.

Item Type:	Article
Authors/Creators:	Bezabih, YW and Sabiiti, W and Alamneh, E and Bezabih, A and Peterson, GM and Bezabhe, WM and Roujeinikova, A
Keywords:	ESBL
Journal or Publication Title:	Journal of Antimicrobial Chemotherapy
Publisher:	Oxford Univ Press
ISSN:	0305-7453
DOI / ID Number:	10.1093/jac/dkaa399
Copyright Information:	Copyright 2020 The Authors
Related URLs:	UTAS Profile: Peterson, GM Google Scholar: Bezabhe, WM
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