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Association between flavonoid intake and risk of hypertension in two cohorts of Australian women: a longitudinal study

do Rosario, VA, Schoenaker, DAJM, Kent, K ORCID: 0000-0002-5330-7044, Weston-Green, K and Charlton, K 2020 , 'Association between flavonoid intake and risk of hypertension in two cohorts of Australian women: a longitudinal study' , European Journal of Nutrition , doi: 10.1007/s00394-020-02424-9.

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Purpose: Epidemiological evidence suggests higher dietary favonoid intake is associated with lower risk of several chronicdiseases. This study aimed to investigate the association between intake of favonoids and their subclasses, and incidence ofhypertension among Australian women in two age cohorts.Methods: This population-based study included 6599 middle-aged (52.5 ± 1.5 years) and 6099 reproductive-aged(27.5±1.5 years) women from the Australian Longitudinal Study on Women’s Health. Food frequency questionnaires wereused to quantify intake of favonoids by cross‐referencing with the Phenol-Explorer food composition database. GeneralisedEstimating Equation analyses investigated associations with incident hypertension, adjusting for demographic and dietaryvariables and hypertension risk factors.Results: There were 1645 cases (24.9%) of hypertension during 15 years follow-up in the middle-aged cohort and 336 cases(5.5%) during 12 years follow-up in the reproductive-aged cohort. Higher intakes of favones [adjusted relative risk (ARR)for quintile 5 vs. 1: 0.82, 95% CI 0.70–0.97], isofavones (0.86, 0.75–0.99) and favanones (0.83, 0.69–1.00) were associatedwith a lower risk of hypertension in the middle-aged cohort. In the reproductive-aged cohort, higher intakes of favanols(0.70, 0.49–0.99) were associated with a lower risk of hypertension. Key foods that provided these favonoids were oranges,orange juice, apples, red wine and soy milk.Conclusion: Higher intakes of total favonoids and subclasses were associated with a lower risk of hypertension in Australian women. These fndings can be used in nutrition messaging and policies for improved cardiovascular health of women.

Item Type: Article
Authors/Creators:do Rosario, VA and Schoenaker, DAJM and Kent, K and Weston-Green, K and Charlton, K
Keywords: flavonoid, blood pressure, hypertension, diet, cohort, polyphenols
Journal or Publication Title: European Journal of Nutrition
Publisher: Dr Dietrich Steinkopff Verlag
ISSN: 1436-6207
DOI / ID Number: 10.1007/s00394-020-02424-9
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Copyright 2020 Springer-Verlag GmbH Germany, part of Springer Nature

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