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Predictive value of the morphology of proximal tibiofibular joint for total knee replacement in patients with knee osteoarthritis

Zhao, Y, Zhu, Z, Chang, J, Wang, G, Zheng, S, Kwoh, CK, Lynch, J, Hunter, DJ and Ding, C ORCID: 0000-0002-9479-730X 2020 , 'Predictive value of the morphology of proximal tibiofibular joint for total knee replacement in patients with knee osteoarthritis' , Journal of Orthopaedic Research , pp. 1-8 , doi: 10.1002/jor.24862.

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The association between proximal tibiofibular joint (PTFJ) and knee osteoarthritis (OA) has been understudied. The objective of this study was to determine whether the morphology of PTFJ has predictive value for the risk of total knee replacement (TKR). Case knees from Osteoarthritis Initiative participants with TKR at 24-60 months follow up (cases) were 1:1 matched with control knees (no TKR throughout 60 months) by baseline age, sex, and Kellgren-Lawrence grade. PTFJ morphological parameters, including coronal inclination angle (angle α), sagittal inclination angle (angle β), fibular contacting area (S), load-bearing area (Sτ), lateral stress-bolstering area (Sφ), and posterior stress-bolstering area (Sυ) were assessed using coronal and sagittal magnetic resonance imaging (MRI), respectively. Associations of the morphological measures at baseline and the time point before TKR (T0 ) and their changes with TKR risks were examined using conditional logistic regression analyses. Two hundred and twenty-three knees of 193 participants received TKR between 12 and 60 months and therefore were matched with 223 control knees. Of these, 173 paired knees had MRI readings available both at baseline and T0 time point. While baseline angle α was positively associated with TKR risk, other measures at baseline and all measures at T0 were not significantly associated with TKR risk. Changes in S, Sτ, and Sυ were significantly and negatively associated with the risk of TKR (ΔS, odds ratio [OR] = 0.38, 95% confidence interval [CI]: 0.19-0.76; ΔSτ, OR = 0.37, 95% CI: 0.16-0.87; ΔSυ, OR = 0.22, 95% CI: 0.08-0.62, respectively). This data shows that morphological changes of PTFJ predict the risk of TKR, suggesting PTFJ may play a role in knee OA.

Item Type: Article
Authors/Creators:Zhao, Y and Zhu, Z and Chang, J and Wang, G and Zheng, S and Kwoh, CK and Lynch, J and Hunter, DJ and Ding, C
Keywords: imaging biomarkers, magnetic resonance imaging, osteoarthritis, osteoarthritis initiative, proximal tibiofibular joint, total knee replacement
Journal or Publication Title: Journal of Orthopaedic Research
Publisher: Elsevier Sci Ltd
ISSN: 0736-0266
DOI / ID Number: 10.1002/jor.24862
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Copyright 2020 Orthopaedic Research Society. Published by Wiley Periodicals LLC

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