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A systematic review of the association between psychological stress and dementia risk in humans

Stuart, KE ORCID: 0000-0002-7872-4231 and Padgett, C ORCID: 0000-0003-4398-4268 2020 , 'A systematic review of the association between psychological stress and dementia risk in humans' , Journal of Alzheimer's Disease, vol. 78, no. 1 , pp. 335-352 , doi: 10.3233/JAD-191096.

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Background: It has been estimated that one third of dementia cases may be preventable through modifiable lifestyle interventions. Epidemiological evidence suggests a link between stressful life events and aging-related cognitive decline and dementia; however, inherent methodological limitations in examining subjective and biological measures of stress separately leads to interpretive constraints.Objective: The aim of the current study was to conduct a systematic review of the research literature investigating the effect of perceived and biological measures of stress on dementia risk.Methods: A systematic review was conducted of cohort, case-control, longitudinal prospective or retrospective studies examining the association between stress and risk of developing dementia. Studies were identified from a systematic search across major electronic databases from inception to February 2020.Results: Overall, 22 studies were identified including a total of 496,556 participants, approximately 50% were females, with sample sizes ranging from 62-270,977. There was considerable heterogeneity in the definition and measurement of stress. Most of the identified studies reported a significant positive association between stress and dementia risk.Conclusion: Evidenced from the current review is that personality traits linked to increased perceived stress and elevated reported perceived stress, are associated with greater statistical risk for dementia. However, this review highlights that caution must be exhibited in interpreting these findings, as methodological issues with confounding adjustment may mediate these results. Future research should focus on the investigation of stress on dementia risk with a full range of confounding adjustment, and on biological measures of stress.

Item Type: Article
Authors/Creators:Stuart, KE and Padgett, C
Keywords: Alzheimer's disease, cortisol, dementia, distress proneness, neuroticism, perceived stress, stress, vascular dementia
Journal or Publication Title: Journal of Alzheimer's Disease
Publisher: IOS Press
ISSN: 1387-2877
DOI / ID Number: 10.3233/JAD-191096
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Copyright 2020 IOS Press and the authors

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