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Idebenone: When an antioxidant is not an antioxidant

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Gueven, N ORCID: 0000-0003-3782-767X, Ravishankar, P, Eri, RD ORCID: 0000-0003-1688-8043 and Rybalka, E 2021 , 'Idebenone: When an antioxidant is not an antioxidant' , Redox Biology, vol. 38 , pp. 1-9 , doi: 10.1016/j.redox.2020.101812.

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Abstract

Idebenone is a well described drug that was initially developed against dementia. The current literature widelyportrays this molecule as a potent antioxidant and CoQ10 analogue. While numerous papers seem to support thisview, a closer look indicates that the pharmacokinetics of idebenone do not support these claims. A majordiscrepancy between achievable tissue levels, especially in target tissues such as the brain, and doses required toshow the proposed effects, significantly questions our current understanding. This review explains how this hashappened and highlights the discrepancies in the current literature. More importantly, based on some recentdiscoveries, a new framework is presented that can explain the mode of action of this molecule and can alignformerly contradictory results. Finally, this new appreciation of the molecular activities of idebenone provides arational approach to test idebenone in novel indications that might have not been considered previously for thisdrug.

Item Type: Article
Authors/Creators:Gueven, N and Ravishankar, P and Eri, RD and Rybalka, E
Keywords: idebenone, antioxidant, radical scavenger
Journal or Publication Title: Redox Biology
Publisher: Elsevier BV
ISSN: 2213-2317
DOI / ID Number: 10.1016/j.redox.2020.101812
Copyright Information:

Copyright 2020 the Authors

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