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Evolution of myocardial dysfunction in asymptomatic patients at risk of heart failure

Halabi, A, Yang, H, Wright, L, Potter, E, Huynh, Q, Negishi, K ORCID: 0000-0002-9086-2565 and Marwick, TH ORCID: 0000-0001-9065-0899 2020 , 'Evolution of myocardial dysfunction in asymptomatic patients at risk of heart failure' , JACC: Cardiovascular Imaging, no. Novemb , pp. 1-12 , doi: 10.1016/j.jcmg.2020.09.032.

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Abstract

Objectives: The determinants of changes in systolic and diastolic parameters in patients aged >65 years, at risk of heart failure (HF), and with and without asymptomatic type 2 diabetes mellitus (T2DM) was assessed by echocardiography. The association between metformin and myocardial function was also assessed.Background: The increasing prevalence of T2DM will likely further fuel the epidemic of HF. Understanding the development or progression of left ventricular (LV) dysfunction may inform effective measures for HF prevention.Methods: A total of 982 patients with at least one HF risk factor (hypertension, obesity, or T2DM) were recruited from 2 community-based populations and divided into 2 groups: T2DM (n = 431, age 71 ± 4 years) and non-T2DM (n = 551, age 71 ± 5 years). Associations of metformin therapy were evaluated in the T2DM group. All underwent a comprehensive echocardiogram, including global longitudinal strain (GLS) and diastolic function (transmitral flow [E], annular velocity [e']) at baseline and follow-up (median 19 months [interquartile range: 17-26]). Comparisons were facilitated by propensity matching.Results: A reduction in GLS was observed in the T2DM group (baseline -17.8 ± 2.6% vs. follow-up -17.4 ± 2.8%; p = 0.003), but not in the non-T2DM group (-18.7 ± 2.7% vs. -18.6 ± 3.0%; p = 0.41). Estimated LV filling pressures increased in both the T2DM group (p = 0.001) and the non-T2DM group (p = 0.04). Metformin-treated patients with T2DM did not increase estimated LV filling pressure (E/e' baseline 8.9 ± 2.7 vs. follow-up 9.1 ± 2.7; p = 0.485) or change e' (7.6 ± 1.5 cm/s vs. 7.6 ± 1.8 cm/s; p = 0.88). After propensity matching, metformin was associated with a smaller change in e' (β = 0.58 [95% CI 0.13 to 1.03]; p = 0.013) and E/e' (β = -0.96 [95% CI -1.66 to -0.26]; p = 0.007) but was not associated with a change in GLS (p = 0.46).Conclusions: Over 2 years, there is a worsening of GLS and LV filling pressures in asymptomatic diabetic patients with HF risk factors. Metformin use is associated with less deterioration of LV filling pressures and myocardial relaxation but had no association with systolic function.

Item Type: Article
Authors/Creators:Halabi, A and Yang, H and Wright, L and Potter, E and Huynh, Q and Negishi, K and Marwick, TH
Keywords: diastolic dysfunction, metformin, myocardial strain, type 2 diabetes mellitus
Journal or Publication Title: JACC: Cardiovascular Imaging
Publisher: Elsevier Inc.
ISSN: 1936-878X
DOI / ID Number: 10.1016/j.jcmg.2020.09.032
Copyright Information:

Copyright 2020 Elsevier

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