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Emerging therapeutic potential of the iridoid molecule, asperuloside: A snapshot of its underlying molecular mechanisms

Chan, Y, Ng, SW, Xin Tan, JZ, Gupta, G, Tambuwala, MM, Bakshi, HA, Dureja, H, Dua, K, Ishaq, M, Caruso, V ORCID: 0000-0002-0523-6149 and Chellappan, DK 2020 , 'Emerging therapeutic potential of the iridoid molecule, asperuloside: A snapshot of its underlying molecular mechanisms' , Chemico-Biological Interactions, vol. 315 , pp. 1-10 , doi: 10.1016/j.cbi.2019.108911.

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Abstract

Over the years, the attention of researchers in the field of modern drug discovery and development has become further intense on the identification of active compounds from plant sources and traditional remedies, as they exhibit higher therapeutic efficacies and improved toxicological profiles. Among the large diversity of plant extracts that have been discovered and explored for their potential therapeutic benefits, asperuloside, an iridoid glycoside, has been proven to provide promising effects as a therapeutic agent for several diseases. Although, this potent substance exists in several genera, it is primarily found in plants belonging to the genus Eucommia. Recent decades have seen a surge in the research on Asperuloside, making it one of the most studied natural products in the field of medicine and pharmacology. In this review, we have attempted to study the various reported mechanisms of asperuloside that form the basis of its wide spectrum of pharmacological activities.

Item Type: Article
Authors/Creators:Chan, Y and Ng, SW and Xin Tan, JZ and Gupta, G and Tambuwala, MM and Bakshi, HA and Dureja, H and Dua, K and Ishaq, M and Caruso, V and Chellappan, DK
Keywords: asperuloside, anti-obesity, anti-inflammatory, anti-cancer, anti-bacterial laxative
Journal or Publication Title: Chemico-Biological Interactions
Publisher: Elsevier
ISSN: 0009-2797
DOI / ID Number: 10.1016/j.cbi.2019.108911
Copyright Information:

Copyright 2019 Elsevier Ltd.

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