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Endogenous anti-cancer candidates in GPCR, ER stress, and EMT

Gundamaraju, R, Lu, W, Azimi, I ORCID: 0000-0001-9477-9999, Eri, R ORCID: 0000-0003-1688-8043 and Sohal, SS ORCID: 0000-0001-9627-6498 2020 , 'Endogenous anti-cancer candidates in GPCR, ER stress, and EMT' , Biomedicines, vol. 8, no. 10 , pp. 1-13 , doi: 10.3390/biomedicines8100402.

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Abstract

The majority of cellular responses to external stimuli are mediated by receptors such as Gprotein-coupled receptors (GPCRs) and systems including endoplasmic reticulum stress (ER stress).Since GPCR signalling is pivotal in numerous malignancies, they are widely targeted by a number ofclinical drugs. Cancer cells often negatively modulate GPCRs in order to survive, proliferate and todisseminate. Similarly, numerous branches of the unfolded protein response (UPR) act as pro-survivalmediators and are involved in promoting cancer progression via mechanisms such as epithelial tomesenchymal transition (EMT). However, there are a few proteins among these groups which impededeleterious effects by orchestrating the pro-apoptotic phenomenon and paving a therapeutic pathway.The present review exposes and discusses such critical mechanisms and some of the key processesinvolved in carcinogenesis.

Item Type: Article
Authors/Creators:Gundamaraju, R and Lu, W and Azimi, I and Eri, R and Sohal, SS
Keywords: ER stress, lung, GPCR, COPD, epithelium, fibrosis, EMT, Cancer, ICS, inflammation
Journal or Publication Title: Biomedicines
Publisher: MDPI AG
ISSN: 2227-9059
DOI / ID Number: 10.3390/biomedicines8100402
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