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Abstract

The majority of cellular responses to external stimuli are mediated by receptors such as Gprotein-coupled receptors (GPCRs) and systems including endoplasmic reticulum stress (ER stress).Since GPCR signalling is pivotal in numerous malignancies, they are widely targeted by a number ofclinical drugs. Cancer cells often negatively modulate GPCRs in order to survive, proliferate and todisseminate. Similarly, numerous branches of the unfolded protein response (UPR) act as pro-survivalmediators and are involved in promoting cancer progression via mechanisms such as epithelial tomesenchymal transition (EMT). However, there are a few proteins among these groups which impededeleterious effects by orchestrating the pro-apoptotic phenomenon and paving a therapeutic pathway.The present review exposes and discusses such critical mechanisms and some of the key processesinvolved in carcinogenesis.

Item Type:	Article
Authors/Creators:	Gundamaraju, R and Lu, W and Azimi, I and Eri, R and Sohal, SS
Keywords:	ER stress, lung, GPCR, COPD, epithelium, fibrosis, EMT, Cancer, ICS, inflammation
Journal or Publication Title:	Biomedicines
Publisher:	MDPI AG
ISSN:	2227-9059
DOI / ID Number:	https://doi.org/10.3390/biomedicines8100402
Copyright Information:	Copyright unknown
Related URLs:	Google Scholar: Azimi, I Google Scholar: Eri, R UTAS Profile: Eri, R Google Scholar: Sohal, SS UTAS Profile: Sohal, SS
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