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Abstract

Probiotics have been widely used in maintaining gastrointestinal health, despite their actual mechanism remaining obscure. There are several hypotheses behind the beneficial effects of probiotics including the regulation of intestinal barrier function and improvement in immune responses in the gastrointestinal system. Multiple probiotics have been introduced in the market as effective dietary supplements in improving gastrointestinal integrity, but there are no or few studies that demonstrate their underlying mechanism. In the current study, we investigated and compared the efficacy of four probiotics (based on different bacterial species) in refining gastrointestinal health by improving mucus biosynthesis and intestinal immune response under in-vitro conditions. By analyzing the gene expression of mucus biosynthesis and intestinal immune response markers, we found that probiotic Streptococcus thermophilusUASt-09 showed promising potential in refining mucosal barrier and gastrointestinal health in human colonic epithelial cells, as compared to other commercial probiotics.

Item Type:	Article
Authors/Creators:	Shastri, MD and Chong, WC and Vemuri, R and Martoni, CJ and Adhikari, S and Bhullar, HK and Kunde, D and Tristram, SG and Eri, RD
Keywords:	probiotics, Mucin-2, goblet cells, intestinal peptides, immunomodulation
Journal or Publication Title:	Microorganisms
Publisher:	MDPI AG
ISSN:	2076-2607
DOI / ID Number:	10.3390/microorganisms8111758
Copyright Information:	Copyright unknown
Related URLs:	UTAS Profile: Shastri, MD UTAS Profile: Kunde, D Google Scholar: Tristram, SG UTAS Profile: Tristram, SG Google Scholar: Eri, RD UTAS Profile: Eri, RD
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