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Association between influenza vaccine administration and primary care consultations for respiratory infections: Sentinel network study of five seasons (2014/2015–2018/2019) in the UK

Parimalanathan, V, Joy, M, Van Dam, PJ ORCID: 0000-0003-3341-6793, Fan, X and de Lusignan, S 2021 , 'Association between influenza vaccine administration and primary care consultations for respiratory infections: Sentinel network study of five seasons (2014/2015–2018/2019) in the UK' , International Journal of Environmental Research and Public Health, vol. 18, no. 2 , pp. 1-13 , doi: https://doi.org/10.3390/ijerph18020523.

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Abstract

Influenza, a vaccine preventable disease, is a serious global public health concern whichresults in a considerable burden on the healthcare system. However, vaccine hesitancy is increasinglybecoming a global problem. One prevalent misconception is that influenza vaccinations can causethe flu. We carried out this study to determine whether people undertaking influenza vaccinationpresented less with acute respiratory tract infection (ARTI) and influenza-like-illness (ILI) followingvaccination. We utilised the Oxford Royal College of General Practitioners Research and SurveillanceCentre sentinel database to examine English patients who received vaccination between 2014/2015and 2018/2019. Of the 3,841,700 influenza vaccinations identified, vaccination details and primarycare respiratory consultation counts were extracted to calculate the relative incidence (RI) per exposure risk period using the self-controlled case series methodology. Results showed a significantincrease in the RI of respiratory consultation rates within fourteen days of vaccination across all fiveyears. Less than 6.2% of vaccinations led to consultations for ARTI or ILI in primary care (crudeconsultation rate 6196 per 100,000). These findings, particularly if confirmed in further research, mayreduce the risk of cross-infection between waiting patients and increase uptake of influenza vaccine.

Item Type: Article
Authors/Creators:Parimalanathan, V and Joy, M and Van Dam, PJ and Fan, X and de Lusignan, S
Keywords: influenza vaccine, general practice, vaccine hesitancy, primary care
Journal or Publication Title: International Journal of Environmental Research and Public Health
Publisher: MDPI
ISSN: 1660-4601
DOI / ID Number: https://doi.org/10.3390/ijerph18020523
Copyright Information:

Copyright 2021 by the authors. Licensee MDPI, Basel, Switzerland.This article is an open access articledistributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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