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Abstract

Reservoir pressure parameters (i.e., reservoir pressure [RP] and excess pressure [XSP]) independently predict cardiovascular events in adults, but this has not been investigated in children. This study aimed to determine (1) the association of reservoir pressure parameters with carotid intima-media thickness (carotid IMT), a preclinical vascular phenotype, and (2) whether a multivariable regression model with or without reservoir pressure parameters fits better for estimating carotid IMT in children. Study participants were 11-12-year-old children (n = 1231, 50% male) from the Child Health CheckPoint study, a cross-sectional substudy of the population-based Longitudinal Study of Australian Children. RP and XSP were obtained using brachial-cuff oscillometry (SphygmoCor XCEL, AtCor, Sydney). Carotid IMT was quantified by vascular ultrasonography. XSP was associated with carotid IMT after adjusting for confounders including age, sex, BMI z-score, heart rate, pubertal stage, moderate-to-vigorous physical activity, and mean arterial pressure (β = 0.93 µm, 95% CI 0.30-1.56 for XSP peak and β = 0.04 µm, 95% CI 0.01-0.08 for XSP integral). The results of the likelihood ratio test indicated a trend that the model with XSP and the above confounders fit better than a similar model without XSP for estimating carotid IMT. Our findings indicate that brachial-cuff device-measured XSP is associated with carotid IMT independent of conventional cardiovascular risk factors, including standard BP. This implies that a clinically convenient cuff approach could provide meaningful information for the early assessment of cardiovascular risk among children.

Item Type:	Article
Authors/Creators:	Peng, X and Picone, DS and Schultz, MG and Cai, G and Wake, M and Burgner, DP and Mynard, JP and Ellul, S and Cheung, M and Juonala, M and Sharman, JE
Keywords:	atherosclerosis, blood pressure monitor, childhood, waveform analysis
Journal or Publication Title:	Hypertension Research
Publisher:	Japanese Soc Hypertension Cent Academic Soc
ISSN:	0916-9636
DOI / ID Number:	10.1038/s41440-020-00576-z
Copyright Information:	Copyright 2020 The Japanese Society of Hypertension
Related URLs:	Google Scholar: Picone, DS Google Scholar: Schultz, MG UTAS Profile: Schultz, MG Google Scholar: Sharman, JE UTAS Profile: Sharman, JE
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