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Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain

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Cullen, CL ORCID: 0000-0001-6929-6258, Pepper, RE, Clutterbuck, MT, Pitman, KA ORCID: 0000-0003-3198-9336, Oorschot, V, Auderset, L, Tang, AD, Ramm, G, Emery, B, Rodger, J, Jolivet, RB and Young, KM ORCID: 0000-0002-1686-3463 2021 , 'Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain' , Cell Reports , doi: 10.1016/j.celrep.2020.108641.

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Abstract

Central nervous system myelination increases action potential conduction velocity. However, it is unclearhow myelination is coordinated to ensure the temporally precise arrival of action potentials and facilitate information processing within cortical and associative circuits. Here, we show that myelin sheaths, supportedby mature oligodendrocytes, remain plastic in the adult mouse brain and undergo subtle structural modifications to influence action potential conduction velocity. Repetitive transcranial magnetic stimulation andspatial learning, two stimuli that modify neuronal activity, alter the length of the nodes of Ranvier and thesize of the periaxonal space within active brain regions. This change in the axon-glial configuration is independent of oligodendrogenesis and robustly alters action potential conduction velocity. Because aptitudein the spatial learning task was found to correlate with action potential conduction velocity in the fimbriafornix pathway, modifying the axon-glial configuration may be a mechanism that facilitates learning in theadult mouse brain.

Item Type: Article
Authors/Creators:Cullen, CL and Pepper, RE and Clutterbuck, MT and Pitman, KA and Oorschot, V and Auderset, L and Tang, AD and Ramm, G and Emery, B and Rodger, J and Jolivet, RB and Young, KM
Keywords: myelin, nodes of Ranvier, periaxonal space, oligodendrocyte, learning, transcranial magnetic stimulation
Journal or Publication Title: Cell Reports
Publisher: Cell Press
ISSN: 2211-1247
DOI / ID Number: 10.1016/j.celrep.2020.108641
Copyright Information:

Copyright 2020 The Authors. This is an open access article under the CC BY-NC-ND license

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