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Uric acid and blood pressure: exploring the role of uric acid production in The Maastricht Study

Scheepers, LEJM ORCID: 0000-0001-6792-8506, Boonen, A, Dagnelie, PC, Schram, MT, van der Kallen, CJH, Henry, RMA, Kroon, AA, Stehouwer, CDA and Arts, ICW 2017 , 'Uric acid and blood pressure: exploring the role of uric acid production in The Maastricht Study' , Journal of Hypertension, vol. 35, no. 10 , pp. 1968-1975 , doi: 10.1097/HJH.0000000000001417.

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Abstract

Objective: Accumulation of reactive oxygen species by increased uric acid production has been suggested as a possible underlying mechanism for the association between uric acid and high blood pressure (BP). We, therefore, investigated the association between serum uric acid concentration and 24-h urinary uric acid excretion, as proxy for uric acid production, with ambulatory 24-h blood pressure and hypertension.Methods: Cross-sectional analyses were conducted among 2555 individuals [52% men, mean age 60.0 ± 8.2 years; 27% type 2 diabetes (by design)] from The Maastricht Study. Multivariable regression analyses were performed to investigate the association of serum uric acid and 24-h urinary uric acid excretion with 24-h pulse pressure, 24-h mean arterial pressure (MAP), and hypertension.Results: After adjustment for traditional hypertension risk factors, serum uric acid concentration (per SD of 81 μmol/l) was associated with higher 24-h MAP [β 0.63 mmHg; confidence interval (CI) 0.27-1.00] and positively associated with hypertension (odds ratio 1.43; CI 1.27-1.61). Urinary uric acid excretion (per SD of 140 mg/day/1.73 m) was associated with higher 24-h MAP (β 0.79 mmHg; CI 0.46-1.12) and with hypertension (odds ratio 1.13; CI 1.02-1.25). There was no significant association between serum and 24-h urinary uric acid excretion with 24-h pulse pressure. There was no interaction with sex or age for the aforementioned associations.Conclusion: Higher serum and urinary uric acid concentrations were associated with higher 24-h MAP and hypertension. These results suggest that serum and 24-urinary uric acid concentrations, the latter as proxy for uric acid production are, independent of each other, associated with BP and hypertension.

Item Type: Article
Authors/Creators:Scheepers, LEJM and Boonen, A and Dagnelie, PC and Schram, MT and van der Kallen, CJH and Henry, RMA and Kroon, AA and Stehouwer, CDA and Arts, ICW
Keywords: urate, uric acid, blood pressure, hypertension, epidemiology. metabolite
Journal or Publication Title: Journal of Hypertension
Publisher: Lippincott Williams & Wilkins
ISSN: 0263-6352
DOI / ID Number: 10.1097/HJH.0000000000001417
Copyright Information:

Copyright 2017 Wolters Kluwer Health

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