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Evolution and lineage dynamics of a transmissible cancer in Tasmanian devils

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Kwon, YM, Gori, K, Park, N, Potts, N, Swift, K, Wang, J, Stammnitz, MR, Cannell, N, Baez-Ortega, A, Comte, S, Fox, S, Harmsen, C, Huxtable, S, Jones, M ORCID: 0000-0001-7558-9022, Kreiss, A, Lawrence, C, Lazenby, B, Peck, S, Pye, R ORCID: 0000-0002-1001-3329, Woods, G ORCID: 0000-0001-8421-7917, Zimmermann, M, Wedge, DC, Pemberton, D, Stratton, MR, Hamede, R ORCID: 0000-0003-1526-225X and Murchison, EP 2020 , 'Evolution and lineage dynamics of a transmissible cancer in Tasmanian devils' , PLoS Biology, vol. 18, no. 11 , pp. 1-33 , doi: 10.1371/journal.pbio.3000926.

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Abstract

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Devil facial tumour 1 (DFT1) is a transmissible cancer clone endangering the Tasmanian devil. The expansion of DFT1 across Tasmania has been documented, but little is known of its evolutionary history. We analysed genomes of 648 DFT1 tumours collected throughout the disease range between 2003 and 2018. DFT1 diverged early into five clades, three spreading widely and two failing to persist. One clade has replaced others at several sites, and rates of DFT1 coinfection are high. DFT1 gradually accumulates copy number variants (CNVs), and its telomere lengths are short but constant. Recurrent CNVs reveal genes under positive selection, sites of genome instability, and repeated loss of a small derived chromosome. Cultured DFT1 cell lines have increased CNV frequency and undergo highly reproducible convergent evolution. Overall, DFT1 is a remarkably stable lineage whose genome illustrates how cancer cells adapt to diverse environments and persist in a parasitic niche.

Item Type: Article
Authors/Creators:Kwon, YM and Gori, K and Park, N and Potts, N and Swift, K and Wang, J and Stammnitz, MR and Cannell, N and Baez-Ortega, A and Comte, S and Fox, S and Harmsen, C and Huxtable, S and Jones, M and Kreiss, A and Lawrence, C and Lazenby, B and Peck, S and Pye, R and Woods, G and Zimmermann, M and Wedge, DC and Pemberton, D and Stratton, MR and Hamede, R and Murchison, EP
Keywords: Tasmanian devil, disease, DFTD, tumour evolution
Journal or Publication Title: PLoS Biology
Publisher: Public Library of Science
ISSN: 1544-9173
DOI / ID Number: 10.1371/journal.pbio.3000926
Copyright Information:

Copyright 2020 Kwon et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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