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Cannabis sativa: interdisciplinary strategies and avenues for medical and commercial progression outside of CBD and THC


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Oultram, JMJ, Pegler, JL, Bowser, TA, Ney, LJ, Eamens, AL and Grof, CPL 2021 , 'Cannabis sativa: interdisciplinary strategies and avenues for medical and commercial progression outside of CBD and THC' , Biomedicines, vol. 9, no. 3 , doi: 10.3390/biomedicines9030234.

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Cannabis sativa (Cannabis) is one of the world’s most well-known, yet maligned plantspecies. However, significant recent research is starting to unveil the potential of Cannabis to producesecondary compounds that may offer a suite of medical benefits, elevating this unique plantspecies from its illicit narcotic status into a genuine biopharmaceutical. This review summarises thelengthy history of Cannabis and details the molecular pathways that underpin the production of keysecondary metabolites that may confer medical efficacy. We also provide an up-to-date summaryof the molecular targets and potential of the relatively unknown minor compounds offered by theCannabis plant. Furthermore, we detail the recent advances in plant science, as well as syntheticbiology, and the pharmacology surrounding Cannabis. Given the relative infancy of Cannabis research,we go on to highlight the parallels to previous research conducted in another medically relevant andversatile plant, Papaver somniferum (opium poppy), as an indicator of the possible future directionof Cannabis plant biology. Overall, this review highlights the future directions of cannabis researchoutside of the medical biology aspects of its well-characterised constituents and explores additionalavenues for the potential improvement of the medical potential of the Cannabis plant.

Item Type: Article
Authors/Creators:Oultram, JMJ and Pegler, JL and Bowser, TA and Ney, LJ and Eamens, AL and Grof, CPL
Keywords: cannabinoids, cannabis, tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinoid receptors (CB1 and CB2 )
Journal or Publication Title: Biomedicines
Publisher: MDPI AG
ISSN: 2227-9059
DOI / ID Number: 10.3390/biomedicines9030234
Copyright Information:

Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.This article is an open access article distributed under the terms andconditions of the Creative Commons Attribution (CC BY) license (

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