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Predicting deseasonalised serum 25 hydroxy vitamin D concentrations in the D-Health Trial: An analysis using boosted regression trees

Waterhouse, M, Baxter, C, Duarte Romero, B, McLeod, DSA, English, DR, Armstrong, BK, Clarke, MW, Ebeling, PR, Hartel, G, Kimlin, MG, O'Connell, RL, Pham, H, Rodney Harris, RM, van der Pols, JC, Venn, AJ ORCID: 0000-0001-7090-1398, Webb, PM, Whiteman, DC and Neale, RE 2021 , 'Predicting deseasonalised serum 25 hydroxy vitamin D concentrations in the D-Health Trial: An analysis using boosted regression trees' , Contemporary Clinical Trials, vol. 104 , pp. 1-11 , doi: 10.1016/j.cct.2021.106347.

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Abstract

Background: The D-Health Trial aims to determine whether monthly high-dose vitamin D supplementation can reduce the mortality rate and prevent cancer. We did not have adequate statistical power for subgroup analyses, so could not justify the high cost of collecting blood samples at baseline. To enable future exploratory analyses stratified by baseline vitamin D status, we developed models to predict baseline serum 25 hydroxy vitamin D [25(OH)D] concentration.Methods: We used data and serum 25(OH)D concentrations from participants who gave a blood sample during the trial for compliance monitoring and were randomised to placebo. Data were partitioned into training (80%) and validation (20%) datasets. Deseasonalised serum 25(OH)D concentrations were dichotomised using cut-points of 50, 60 and 75 nmol/L. We fitted boosted regression tree models, based on 13 predictors, and evaluated model performance using the validation data.Results: The training and validation datasets had 1788 (10.5% Conclusions: We exploited compliance monitoring data to develop models to predict serum 25(OH)D concentration for D-Health participants at baseline. This approach may prove useful in other trial settings where there is an obstacle to exhaustive data collection.

Item Type: Article
Authors/Creators:Waterhouse, M and Baxter, C and Duarte Romero, B and McLeod, DSA and English, DR and Armstrong, BK and Clarke, MW and Ebeling, PR and Hartel, G and Kimlin, MG and O'Connell, RL and Pham, H and Rodney Harris, RM and van der Pols, JC and Venn, AJ and Webb, PM and Whiteman, DC and Neale, RE
Journal or Publication Title: Contemporary Clinical Trials
Publisher: Elsevier
ISSN: 1551-7144
DOI / ID Number: 10.1016/j.cct.2021.106347
Copyright Information:

© 2021 Elsevier

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