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The associations of childhood adiposity with menopausal symptoms in women aged 45-49 years: An Australian Cohort Study

He, Y, Tian, J ORCID: 0000-0001-7746-7782, Oddy, WH ORCID: 0000-0002-6119-7017, Blizzard, L ORCID: 0000-0002-9541-6943, Dwyer, T, Hickey, M and Venn, AJ ORCID: 0000-0001-7090-1398 2021 , 'The associations of childhood adiposity with menopausal symptoms in women aged 45-49 years: An Australian Cohort Study' , Maturitas, vol. 143 , pp. 81-88 , doi: 10.1016/j.maturitas.2020.09.008.

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Abstract

Objectives: To examine the associations of childhood adiposity with menopausal symptoms in women aged 45-49 years.Study design: National population-based cohort study of 334 girls prospectively followed from childhood (aged 11-15) through to midlife (aged 45-49). Childhood overweight and obesity were defined by international age- and sex-specific standards for body mass index (BMI), and abdominal obesity was defined as waist/height ratio≥0.5.Main outcome measures: Vasomotor symptoms (VMS), vaginal dryness, total menopausal symptoms and domain-specific symptoms (somatic, psychological and urogenital) were measured during 2018-19 using the Menopause Rating Scale (MRS) and classified as none, mild, moderate or severe.Results: The prevalence of mild, moderate and severe VMS was 24.0 %, 9.0 % and 3.9 %, and of vaginal dryness was 12.6 %, 4.8 % and 2.4 %. No significant associations of childhood overweight/obesity or abdominal obesity with VMS or vaginal dryness were found after adjustment for childhood age, follow-up length, smoking, socioeconomic status and diet quality. Childhood overweight/obesity was associated with increased risks of more severe total (RR:1.17, 95 % CI:1.02-1.36), psychological (RR:1.19, 95 % CI:1.04-1.35) and urogenital (RR:1.29, 95 % CI:1.14-1.46) symptoms measured using the MRS. Associations with childhood abdominal obesity were mostly stronger with more severe total (RR:2.19, 95 % CI:1.48-3.23), somatic (RR:1.52, 95 % CI:1.15-2.02), psychological (RR:1.21, 95 % CI:1.04-1.42) and urogenital (RR:2.11, 95 % CI:1.39-3.20) symptoms.Conclusions: Childhood adiposity was not associated with increased risks of more severe VMS or vaginal dryness in women aged 45-49 years. Childhood adiposity, especially abdominal obesity, was associated with more severe total, somatic, psychological and urogenital symptoms. However, the association between these symptoms and menopause is not established.

Item Type: Article
Authors/Creators:He, Y and Tian, J and Oddy, WH and Blizzard, L and Dwyer, T and Hickey, M and Venn, AJ
Keywords: childhood adiposity, menopausal symptoms, vaginal dryness, vasomotor symptoms
Journal or Publication Title: Maturitas
Publisher: Elsevier/North Holland Biomedical Press
ISSN: 0378-5122
DOI / ID Number: 10.1016/j.maturitas.2020.09.008
Copyright Information:

2020 Elsevier B.V.

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