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The cross-sectional and longitudinal associations of dietary patterns with knee symptoms and MRI detected structure in patients with knee osteoarthritis

Zheng, S, Wu, F ORCID: 0000-0003-3753-974X, Winzenberg, T ORCID: 0000-0002-4112-3491, Cicuttini, F, Wluka, AE, Antony, B ORCID: 0000-0001-8704-6084, Aitken, D ORCID: 0000-0001-5685-7634, Blizzard, L ORCID: 0000-0002-9541-6943 and Ding, C ORCID: 0000-0002-9479-730X 2021 , 'The cross-sectional and longitudinal associations of dietary patterns with knee symptoms and MRI detected structure in patients with knee osteoarthritis' , Osteoarthritis and Cartilage: Journal of The Osteoarthritis Research Society International , doi: 10.1016/j.joca.2020.12.023.

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Abstract

Objectives: To examine the cross-sectional and longitudinal associations of dietary patterns with kneesymptoms and structures in patients with knee osteoarthritis (OA).Methods: Participants with symptomatic knee OA were recruited from a randomised, placebo-controlledtrial conducted in Tasmania (N ¼ 259) and Victoria (N ¼ 133). Diet was assessed by the Anti-CancerCouncil of Victoria food frequency questionnaire. Factor analysis was used to identify dietary patterns.Knee symptoms were assessed using Western Ontario and McMaster Universities Arthritis Index(WOMAC) and structures using MRI. Multivariable linear regressions were used to examine associations.Results: Three dietary patterns (“high-fat”, “healthy” and “mixed”) were identified in whole sample.Participants with higher “healthy pattern” score had lower total WOMAC, pain, function and stiffnessscores at baseline but the associations were not significant over 24 months. Three (“western”, “vegetableand meat” and “mediterranean”) and two (“processed” and “vegetable”) patterns were identified inTasmania and Victoria, respectively. Cross-sectionally, only “mediterranean pattern” and “vegetablepattern” scores were significantly and negatively associated with total WOMAC or function scores.Longitudinally, participants with higher “western pattern” had worsening function (b: 0.35, 95%CI: 0.03,0.67) and total WOMAC (b: 0.40, 95%CI: 0.07, 0.72) scores; furthermore, “vegetable pattern” was associated with decreased WOMAC stiffness score (b: 0.47, 95%CI: 0.93, 0.02). In contrast, dietary patterns were largely not associated with structural changes.Conclusion: Some healthy dietary patterns were associated with reduced joint symptoms but dietarypatterns were not associated with joint structure in this sample with knee OA. Further studies arerequired to confirm these findings.

Item Type: Article
Authors/Creators:Zheng, S and Wu, F and Winzenberg, T and Cicuttini, F and Wluka, AE and Antony, B and Aitken, D and Blizzard, L and Ding, C
Keywords: osteoarthritis, diet, pain, MRI
Journal or Publication Title: Osteoarthritis and Cartilage: Journal of The Osteoarthritis Research Society International
Publisher: W B Saunders Co Ltd
ISSN: 1063-4584
DOI / ID Number: 10.1016/j.joca.2020.12.023
Copyright Information:

© 2021 Osteoarthritis Research Society International. Published by Elsevier

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