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Differences in fatigue-like behavior in the lipopolysaccharide and poly I:C inflammatory animal models

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Foster, CG, Landowski, LM ORCID: 0000-0001-6195-8536, Sutherland, BA ORCID: 0000-0002-0791-0950 and Howells, DW ORCID: 0000-0002-2512-7724 2021 , 'Differences in fatigue-like behavior in the lipopolysaccharide and poly I:C inflammatory animal models' , Physiology and Behavior, vol. 232 , pp. 1-10 , doi: 10.1016/j.physbeh.2021.113347.

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Abstract

Central fatigue is a condition associated with impairment of the central nervous system often leading to themanifestation of a range of debilitating symptoms. Fatigue can be a consequence of systemic inflammationfollowing an infection. Administration of lipopolysaccharide (LPS) and polyriboinosinic:polyribocytidlic (poly I:C) to animals can induce systemic inflammation by mimicking a bacterial or viral infection respectively andtherefore have been used as models of fatigue. We evaluated a range of phenotypic behaviors exhibited in the LPSand poly I:C animal models to assess whether they adequately replicate fatigue symptomology in humans. Inaddition to standard observation- and intervention-based behavioral assessments, we used powerful in-cagemonitoring technology to quantify rodent behavior without external interference. LPS and poly I:C treatedSprague Dawley rats displayed ‘sickness behaviors’ of elevated temperature, weight loss and reduced activity inthe open field test and with in-cage monitoring within 24 h post-treatment, but only LPS-treated rats displayedthese behaviors beyond these acute timepoints. Once sickness behavior diminished, LPS-treated rats exhibited anincrease in reward-seeking and motivation behaviors. Overall, these results suggest that the LPS animal modelproduces an extensive and sustained fatigue-like phenotype, whereas the poly I:C model only produced acuteeffects. Our results suggest that the LPS animal model is a more suitable candidate for further studies on centralfatigue-like behavior.

Item Type: Article
Authors/Creators:Foster, CG and Landowski, LM and Sutherland, BA and Howells, DW
Keywords: animal models, inflammation, fatigue, neuroscience, neurology, glut1, aquaporin, LPS, Poly I:C
Journal or Publication Title: Physiology and Behavior
Publisher: Pergamon-Elsevier Science Ltd
ISSN: 0031-9384
DOI / ID Number: 10.1016/j.physbeh.2021.113347
Copyright Information:

Copyright 2021 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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